Juventus look to Federico Chiesa and Alvaro Morata with a revamped defence, while Napoli are down to the bare bones amid COVID, injuries, bans and Africa Cup of Nations duty, but the ‘quarantine’ trio can start.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
There were real doubts as to whether this fixture would go ahead at all, a repeat of the October 2020 incident.
Leonardo Bonucci, Danilo and Aaron Ramsey are injured, with Giorgio Chiellini and Carlo Pinsoglio testing positive for COVID-19.
Arthur Melo had been positive, but received a negative test yesterday and is therefore on the bench.
It means a whole new defence with Daniele Rugani and Matthijs de Ligt, while Chiesa completes the attack with Morata and Federico Bernardeschi.
Napoli have huge problems just picking a starting XI, especially as Luciano Spalletti has COVID-19 and is self-isolating.
Also with COVID are Kevin Malcuit, Victor Osimhen, Fabian Ruiz, Hirving Lozano, Alex Meret and the suspended Mario Rui.
Incredibly, Piotr Zielinski, Amir Rrahmani and Stanislav Lobotka were in doubt until the last second, because their vaccine was over 120 days ago, so they don’t fit the new quarantine guidelines.
However, they posted negative tests today and have therefore been allowed to play.
Kalidou Koulibaly, Andre Frank Zambo Anguissa and Adam Ounas are at the Africa Cup of Nations.
Lorenzo Insigne therefore starts, despite signing for Toronto FC this week from July 1, with Dries Mertens, Matteo Politano and Piotr Zielinski all together.
Eljif Elmas can also play, as he had an inconclusive COVID test, but the second result was negative.
Juventus: Szczesny; Cuadrado, Rugani, De Ligt, Alex Sandro; McKennie, Locatelli, Rabiot; Chiesa, Morata, Bernardeschi
Napoli: Ospina; Di Lorenzo, Rrahmani, Juan Jesus, Ghoulam; Demme, Lobotka; Politano, Zielinski, Insigne; Mertens