Milan are decimated for this tricky trip to Torino, but have the chance to go four points clear as they face Andrea Belotti and Gleison Bremer.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Olimpico Grande Torino in Turin.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Scudetto race continues its unexpected twists and turns, as today Napoli were beaten 3-2 at home by Fiorentina, while Inter defeated Verona 2-0 last night.
That means a victory here will send the Rossoneri four points clear at the top of the table, even if Inter have a game in hand.
However, they go into this game without injured Zlatan Ibrahimovic, Alessandro Florenzi, Ismael Bennacer, Ante Rebic, Alessio Romagnoli, Simon Kjaer and Samu Castillejo.
Olivier Giroud is therefore the only centre-forward available, supported by Rafael Leao, Brahim Diaz and Alexis Saelemaekers.
Torino have Milan-owned midfielder Tommaso Pobega back from suspension with Josip Brekalo and Gallo Belotti.
Rolando Mandragora, Dennis Praet, Antonio Sanabria, Simone Zaza, Mohamed Fares and Koffi Djidji are out of action, so Samuele Ricci steps into midfield.
All eyes will be on Bremer, who has already neutralised Serie A’s top strikers this season and is linked with a move to among others Milan and Inter this summer.
Torino: Berisha; Zima, Bremer, Rodriguez; Singo, Ricci, Lukic, Vojvoda; Pobega, Brekalo; Belotti
Milan: Maignan; Calabria, Kalulu, Tomori, Theo Hernandez; Tonali, Kessie; Saelemaekers, Brahim Diaz, Leao; Giroud