It’s the massive Derby della Capitale, with Nicolò Zaniolo and Tammy Abraham taking on Felipe Anderson and Luis Alberto, with Jose Mourinho and Maurizio Sarri on the touchlines.
It kicks off at the Stadio Olimpico at 17.00 GMT.
This is not only a local derby, but also a head-to-head for the chance to catch Atalanta in third place.
Roma reached the Europa League play-offs midweek, while Lazio were eliminated and drop down to the Conference League.
Paulo Dybala, Leonardo Spinazzola, Georginio Wijnaldum and Ebrima Darboe are all out injured.
Zaniolo came off the bench and transformed Thursday’s game against Ludogorets, so he starts this evening with Lorenzo Pellegrini and Tammy Abraham.
Lazio are missing star striker Ciro Immobile through a thigh injury and midfielder Sergej Milinkovic-Savic with a ban, severely weakening the squad at Sarri’s disposal.
Immobile is named on the bench, even though he cannot play, so he can be close to his teammates.
Felipe Anderson is the False 9 flanked by Mattia Zaccagni and ex-Roma man Pedro, with Luis Alberto pulling the strings.
The Biancocelesti had kept six consecutive Serie A clean sheets until last week’s surprise 3-1 home defeat to Salernitana.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Camara, Zalewski; Zaniolo, Pellegrini; Abraham
Lazio: Provedel; Lazzari, Casale, Romagnoli, Marusic; Luis Alberto, Vecino, Cataldi; Pedro, Felipe Anderson, Zaccagni