Scudetto winners Napoli host Champions League and Coppa Italia Finalists Inter with Victor Osimhen and Kvicha Kvaratskhelia facing Romelu Lukaku and Nicolò Barella.
It kicks off at the Stadio Diego Armando Maradona at 17.00 UK time (16.00 GMT).
The party is still going in Naples, but also tension is building with coach Luciano Spalletti and President Aurelio De Laurentiis hinting there will be a split at the end of the season.
Chucky Lozano is on the treatment table, but Mario Rui returns to the bench, Kvaratskhelia shakes off a knock to start.
Inter are torn between resting players between the Champions League semi-final and Wednesday’s Coppa Italia Final against Fiorentina, but also needing points to secure their top four status in Serie A.
Henrikh Mkhitaryan limped off against Milan and joins Milan Skriniar on the sidelines, while Valentin Carboni is at the Under-20 World Cup, where he scored for Argentina against Uzbekistan last night.
Lukaku leads the way with Joaquin Correa, while the midfield is transformed.
So far this season, Napoli have been able to beat every team in Serie A at least once except for Inter, who won 1-0 at San Siro in January.
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Olivera; Anguissa, Lobotka, Zielinski; Elmas, Osimhen, Kvaratskhelia
Inter: Onana; D’Ambrosio, De Vrij, Bastoni; Bellanova, Barella, Asllani, Gagliardini, Gosens; Lukaku, Correa
Player statistic
| 19' |  |
Roberto Gagliardini | ||
| 41' |  |
Roberto Gagliardini |
| Eljif Elmas | |
64' | ||
| Frank Anguissa (Assist: Piotr Zielinski) |
 |
67' | ||
| 82' | |
Romelu Lukaku (Assist: Federico Dimarco) | ||
| Giovanni Di Lorenzo (Assist: Frank Anguissa) |
|
85' | ||
| Gianluca Gaetano (Assist: Giovanni Simeone) |
|
90+5' |
Match statistic
