Napoli and Fiorentina go head-to-head and the winner will catch Juventus in third place, as Victor Osimhen and Kvicha Kvaratskhelia take on Jonathan Ikone and M’Bala Nzola.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time (18.45 GMT).
Both sides are locked together on 14 points and had midweek European commitments, the Partenopei beaten 3-2 by Real Madrid and the Viola fighting back from 2-0 down to hold Ferencvaros 2-2.
Amir Rrahmani, Juan Jesus and former Fiorentina goalkeeper Pierluigi Gollini are still out of action, so Rudi Garcia makes very few changes to his starting XI.
Fiorentina are missing Dodo, Gaetano Castrovilli, Yerry Mina and goalkeeper Oliver Christensen, who pulled out in the Conference League warm-up with a muscular issue.
Cristiano Biraghi seems to have shaken off a knock to start, while Nzola returns to the attack after he was rested on Thursday, supported by Ikone, Giacomo Bonaventura and Josip Brekalo.
Nico Gonzalez seemed exhausted after that 2-2 draw and is not ready to start.
Napoli: Meret; Di Lorenzo, Ostigard, Natan, Olivera; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia
Fiorentina: Terracciano; Kayode, Milenkovic, Martinez Quarta, Parisi; Arthur, Duncan; Ikone, Bonaventura, Brekalo; Nzola
Player statistic
| 7' |  |
Josip Brekalo | ||
| Victor Osimhen |  |
45+5' | ||
| 45+4' |  |
Pietro Terracciano |
| 63' | |
Giacomo Bonaventura | ||
| 69' | |
Lucas Martínez Quarta | ||
| 70' | |
Giacomo Bonaventura | ||
| 89' | |
Luca Ranieri | ||
| Giovanni Simeone | |
90+1' | ||
| Jens Cajuste | |
90+5' | ||
| 90+3' | |
Nicólas González (Assist: Fabiano Parisi) |
Match statistic
