Milan are in the Champions League semi-final, but dropped down to fifth in Serie A and anything less than three points against troubled Lecce would be disastrous.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
The Rossoneri pushed past favourites Napoli 2-1 on aggregate to set up a Champions League semi-final Derby della Madonnina with Inter.
However, they were held to back-to-back draws in Serie A by Bologna and Empoli, then dropped to fifth place when Juventus partially won the appeal against their 15-point penalty.
The pressure is on, with Davide Calabria suspended, Olivier Giroud and Tommaso Pobega injured, so Ante Rebic leads the way with Brahim Diaz and Rafael Leao.
Lecce had such a great start to the season after promotion from Serie B, but completely lost their way since February, as the 1-1 draw with Sampdoria ended a run of six consecutive defeats.
They drew 2-2 with Milan back in January, fumbling a 2-0 lead.
Milan: Maignan; Kalulu, Thiaw, Tomori, Theo Hernandez; Tonali, Krunic; Messias, Diaz, Leao; Rebic
Lecce: Falcone; Gendrey, Baschirotto, Umtiti, Gallo; Blin, Hjulmand, Oudin; Di Francesco, Ceesay, Banda
Player statistic
| Malick Thiaw |  |
27' | ||
| Rafael Leão (Assist: Sandro Tonali) |
 |
40' |
| Rafael Leão | |
75' |
Match statistic
