Romelu Lukaku and Paulo Dybala lead the way, with Lorenzo Pellegrini returning to captain Roma in the trip to Mateo Retegui’s Genoa.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 19.45 UK time (18.45 GMT).
The Giallorossi had looked as if their season would be kick-started by a 7-0 win over Empoli and narrow Europa League victory away to Sheriff Tiraspol, but stuttered again when held by Torino.
Injury problems continue, with Chris Smalling, Renato Sanches, Marash Kumbulla and Tammy Abraham out, but the good news is that captain Pellegrini returns to support strike partnership Lukaku and Dybala.
Genoa seem to do better against the bigger clubs, beating Lazio and holding Napoli to a 2-2 draw after promotion from Serie B.
Aaron Martin is suspended after the defeat to Lecce, plus Alessandro Vogliacco on the treatment table, but Junior Messias is available on the bench for the first time this season.
Italy international Retegui is the star man, with Albert Gudmundsson in support.
Kevin Strootman faces his former club.
Genoa: Martinez; Bani, Dragusin, Vasquez; Matturro, Strootman, Badelj, Frendrup, Sabelli; Gudmundsson; Retegui
Roma: Rui Patricio; Mancini, Llorente, Ndicka; Kristensen, Cristante, Paredes, Spinazzola; Pellegrini; Dybala, Lukaku
Player statistic
| Albert Gudmundsson (Assist: Kevin Strootman) |
 |
5' | ||
| 22' | |
Bryan Cristante (Assist: Leonardo Spinazzola) | ||
| Kevin Strootman |  |
26' | ||
| Stefano Sabelli | |
37' | ||
| 42' | |
Gianluca Mancini | ||
| Mateo Retegui (Assist: Morten Thorsby) |
|
45' |
| Mateo Retegui | |
65' | ||
| Morten Thorsby (Assist: Radu Dragusin) |
|
74' | ||
| Mattia Bani | |
75' | ||
| 75' | |
Leandro Paredes | ||
| Junior Messias (Assist: Morten Thorsby) |
|
81' | ||
| 89' | |
Houssem Aouar |
Match statistic
