Napoli are the only side who could have a 100 per cent record going into Week 4, with Kvicha Kvaratskhelia and Victor Osimhen visiting Luka Jovic’s Fiorentina with Antonin Barak starting.
It kicks off at the Stadio Artemio Franchi at 19.45 UK time (18.45 GMT).
The Partenopei are flying high after back-to-back wins over Verona and Monza, where they scored nine goals and conceded two.
Georgia international Kvaratskhelia scored three of them and has been a revelation, so he again starts with Osimhen and Chucky Lozano.
New signings Giacomo Raspadori, Giovanni Simeone and Tanguy Ndombele are again on the bench after making their debuts as substitutes against Monza, with Diego Demme and Adam Ounas injured.
Fiorentina qualified for the Conference League with their 2-1 aggregate win over FC Twente, playing in the Netherlands on Thursday.
Gaetano Castrovilli is a long-term absentee following knee surgery, but Vincenzo Italiano has to rotate the squad due to that midweek test.
Jovic and Giacomo Bonaventura are among those returning to the starting XI, but the big news is that new buy Barak is thrown straight into the game after his move from Verona.
Fiorentina: Gollini; Dodo, Milenkovic, Martinez Quarta, Biraghi; Bonaventura, Amrabat, Barak; Ikone, Jovic, Sottil
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia
Who writes your articles. None of the new signings were on the pitch last game.
they were in a friendly @ Napolienspain