Pedro and Taty Castellanos lead the attack for Lazio, while Bologna look to Riccardo Orsolini and Joshua Zirkzee in this head-to-head for position.
It kicks off at the Stadio Dall’Ara at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is the opening fixture of Serie A Week 11 and there is just one point separating these teams in the battle for European places.
Lazio are missing Nicolò Casale in defence, while Alessio Romagnoli is not at 100 per cent either, but the Italian is still able to start.
Taty Castellanos takes the centre-forward role again, despite Ciro Immobile converting a last-gasp penalty to beat Fiorentina, and is joined by Pedro rather than Mattia Zaccagni.
Bologna are unbeaten since the opening weekend against Milan and were also in action midweek in the Coppa Italia.
Lorenzo De Silvestri, Adama Soumaoro and Oussame El Azzouzi are out of action, but Sam Beukema and Jhon Lucumi are available again to lessen the injury crisis in defence.
Bologna: Skorupski; Posch, Beukema, Calafiori, Lykogiannis; Aebischer, Freuler; Orsolini, Ferguson, Saelemaekers; Zirkzee
Lazio: Provedel; Lazzari, Patric, Romagnoli, Marusic; Guendouzi, Rovella, Luis Alberto; Felipe Anderson, Castellanos, Pedro
Player statistic
| 35' |  |
Pedro |
| Lewis Ferguson (Assist: Joshua Zirkzee) |
 |
46' | ||
| Lewis Ferguson | |
50' | ||
| 50' | |
Alessio Romagnoli | ||
| Sam Beukema | |
56' | ||
| 65' | |
Luis Alberto | ||
| 80' | |
Mattia Zaccagni | ||
| 90+6' | |
Gustav Isaksen |
Match statistic
