Matteo Politano is the favourite to start with Radja Nainggolan and Ivan Perisic behind Mauro Icardi against PSV Eindhoven.
It kicks off at the Philips Stadion at 20.00 UK time (19.00 GMT).
The Nerazzurri are on a run of four consecutive victories in all competition, including a dramatic comeback to beat Tottenham Hotspur in the Champions League.
Luciano Spalletti sticks with his ideal XI, as the only doubt is between Politano and Antonio Candreva on the right side of that supporting trio.
Matteo Politano is the favourite to start with Radja Nainggolan and Ivan Perisic behind Mauro Icardi against PSV Eindhoven.
It kicks off at the Philips Stadion at 20.00 UK time (19.00 GMT).
The Nerazzurri are on a run of four consecutive victories in all competition, including a dramatic comeback to beat Tottenham Hotspur in the Champions League.
Luciano Spalletti sticks with his ideal XI, as the only doubt is between Politano and Antonio Candreva on the right side of that supporting trio.
Nainggolan and Perisic provide the supply for Icardi, who scored a sensational volley against Spurs.
Danilo D’Ambrosio has shaken off a knock and can start at right-back with Kwadwo Asamoah on the left.
PSV Eindhoven held out well with Barcelona until capitulating in the final stages for an eventual 4-0 defeat at Camp Nou, sealed by a Lionel Messi hat-trick.
Absent through injury for Coach Mark van Bommel are Ryan Thomas, Dante Rigo and Maximiliano Romero.
The star men to watch out for are striker Luuk de Jong and Mexico international winger Hirving ‘Chucky’ Lozano.
Probable line-ups
PSV Eindhoven: Zoet; Dumfries, Schwaab, Viergever, Angelino; Hendrix, Rosario; Lozano, Pereiro, Bergwijn; De Jong
PSV bench: Room, Sainsbury, Isimat-Mirin, Behich, Gutierrez, Ramselaar, Malen
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar, Asamoah; Vecino, Brozovic; Politano, Nainggolan, Perisic; Icardi
Inter bench: Padelli, Miranda, Vrsaljko, Borja Valero, Candreva, Keita, Lautaro Martinez
Ref: Mazic (SRB)