Jose Mourinho prepares for his debut with Roma against Trabzonspor in Turkey, when Matias Vina and Eldor Shomurodov are expected to start for the Giallorossi.
The match at the Medical Park Stadium kicks off at 18.30 UK time.
The Giallorossi are preparing for their debut in the new UEFA competition and are in Turkey to play Super Lig side Trabzonspor on Thursday night.
Mourinho has to cope without Chris Smalling, who suffered a thigh injury in training and is expected to sit out against Fiorentina this weekend too.
Roger Ibanez is thus expected to start in defence with Gianluca Mancini, with Vina starting at left-back after his arrival from Palmeiras this month.
Lorenzo Pellegrini should return to action after missing the match against Raja Casablanca and Shomurodov should get his first competitive game since joining from Genoa.
Roma (probable): Rui Patricio; Karsdorp, Mancini, Ibanez, Vina; Cristante, Veretout; Zaniolo, Pellegrini, Mkhitaryan; Shomurodov