Carlo Ancelotti has to transform his Napoli line-up amid bans and injuries, but has Dries Mertens back, while Lazio switch Senad Lulic.
It kicks off at 19.30 GMT, click here for a match preview.
The Partenopei are in second place and Aquile must get a result to recapture fourth after Roma beat Torino 3-2 on Saturday.
Ancelotti is forced to reshuffle, as Kalidou Koulibaly, Allan and Lorenzo Insigne are suspended, with captain Marek Hamsik injured.
Carlo Ancelotti has to transform his Napoli line-up amid bans and injuries, but has Dries Mertens back, while Lazio switch Senad Lulic.
It kicks off at 19.30 GMT, click here for a match preview.
The Partenopei are in second place and Aquile must get a result to recapture fourth after Roma beat Torino 3-2 on Saturday.
Ancelotti is forced to reshuffle, as Kalidou Koulibaly, Allan and Lorenzo Insigne are suspended, with captain Marek Hamsik injured.
The good news for the hosts is that Mertens and Raul Albiol appear to have shaken off ankle and knee issues respectively, so Nikola Maksimovic is the favourite rather than Sebastiano Luperto to step in to K2’s shoes.
Amadou Diawara and Piotr Zielinski are expected to take the midfield reins, with Mertens partnering on-form Milik in attack.
Lazio have Adam Marusic suspended and Valon Berisha injured, while Martin Caceres is left out ahead of his imminent transfer to Bologna.
Short on options for the right flank, it’s believed Lulic will move over to that side, leaving Jordan Lukaku on the left.
Lucas Leiva is back to full fitness alongside Sergej Milinkovic-Savic, while Luis Alberto is the favourite rather than Joaquin Correa or Felipe Caicedo as support for native Neapolitan Ciro Immobile.
Napoli (probable): Meret; Hysaj, Albiol, Maksimovic, Ghoulam; Callejon, Diawara, Zielinski, Fabian Ruiz; Mertens, Milik
Lazio (probable): Strakosha; Luiz Felipe, Acerbi, Radu; Lulic, Parolo, Lucas Leiva, Milinkovic-Savic, Lukaku; Luis Alberto; Immobile
Ref: Rocchi