Milan are forced to make big changes for the Europa League Round of 16 with Manchester United, as Fikayo Tomori and Diogo Dalot should start.
The first leg kicks off at Old Trafford on Thursday at 17.55 GMT.
Zlatan Ibrahimovic, Mario Mandzukic, Theo Hernandez, Ismael Bennacer, Ante Rebic and Hakan Calhanoglu have not made the trip.
Captain Alessio Romagnoli is in the squad, but coach Stefano Pioli confirmed to Sky Sport Italia that the defender is in major doubt to feature due to a bruised foot.
Milan are forced to make big changes for the Europa League Round of 16 with Manchester United, as Fikayo Tomori and Diogo Dalot should start.
The first leg kicks off at Old Trafford on Thursday at 17.55 GMT.
Zlatan Ibrahimovic, Mario Mandzukic, Theo Hernandez, Ismael Bennacer, Ante Rebic and Hakan Calhanoglu have not made the trip.
Captain Alessio Romagnoli is in the squad, but coach Stefano Pioli confirmed to Sky Sport Italia that the defender is in major doubt to feature due to a bruised foot.
There are at this stage precious few alternatives for the Rossoneri, as Tomori on loan from Chelsea will partner Simon Kjaer in the centre of defence, with Dalot facing his parent club at left-back.
Soualiho Meite should start in midfield, as Sandro Tonali is only fit enough for the bench, with Rafael Leao the only available striker in a centre-forward role he is not comfortable in.
The only option is between Alexis Saelemaekers and Samu Castillejo on the right side of a supporting trio.
Manchester United have quite a few injury problems too, missing Paul Pogba, Marcus Rashford, Edinson Cavani and Donny van de Beek.
Luke Shaw could be rested in favour of ex-Inter full-back Alex Telles, with Eric Bailly or Victor Lindelof in central defence.
The star man is former Sampdoria midfielder Bruno Fernandes, no stranger to Serie A football.
Man Utd (4-2-3-1): Henderson; Wan-Bissaka, Bailly, Maguire, Shaw; Fred, McTominay; Greenwood, Bruno Fernandes, James; Martial
Milan (4-2-3-1): G Donnarumma; Calabria, Tomori, Kjaer, Dalot; Meite, Kessie; Saelemaekers, Diaz, Krunic; Leao