Maurizio Sarri seems set to start an attacking trident with Pedro, Ciro Immobile and Felipe Anderson when Lazio face Spezia, while Atalanta continue with Luis Muriel up front.
The two matches start at 17.30 UK time.
Lazio continue after a 3-1 win over Empoli in the first match and hope to build on the good start with another three points at the Olimpico.
Sarri is not happy with the conditions of the pitch in Rome and Felipe Luiz will not make it in time for Saturday’s kick-off.
Luis Alberto seems set to start on the bench again, as Sergej Milinkovic-Savic, Lucas Leiva and Akpa Akpro could get the go ahead in a 4-3-3 against Thiago Motta’s men.
Atalanta are wary of Marko Arnautovic, who should start up front for Bologna today, and are still coping without star striker Duvan Zapata.
Ruslan Malinovksyi and Matteo Pessina are expected to start behind Luis Muriel in attack, with Joakim Maehle and Robin Gosens on the sides.
Probable line-ups
Lazio vs. Spezia
Lazio (4-3-3): Reina; Lazzari, Acerbi, Radu, Hysaj; Milinkovic-Savic, Lucas Leiva, Akpa Akpro; Pedro, Immobile, Felipe Anderson
Spezia (3-4-3): Zoet; Petko Hristov, Erlic, Nikolaou; Amian, Maggiore, Bastoni, Ferrer; Verde, Gyasi, Colley
Atalanta vs. Bologna
Atalanta (3-4-2-1): Musso; Toloi, Demiral, Djimsiti; Maehle, Pasalic, Freuler, Gosens; Malinovskyi, Pessina; Muriel
Bologna (4-2-3-1): Skorupski; De Silvestri, Medel, Bonifazi, Hickey; Michael, Dominguez, Orsolini; Vignato, Barrow; Arnautovic