Lazio are expected to start Manuel Lazzari and Lucas Leiva with Ciro Immobile, while Roma revamp with Davide Zappacosta and Gianluca Mancini, moving Alessandro Florenzi up.
The Derby della Capitale kicks off at 17.00 UK time (16.00 GMT), click here for a match preview.
Simone Inzaghi’s men are the favourites going in after their 3-0 victory away to Sampdoria, but they are also more consistent, having changed very little since last season’s Coppa Italia triumph.
Lazio are expected to start Manuel Lazzari and Lucas Leiva with Ciro Immobile, while Roma revamp with Davide Zappacosta and Gianluca Mancini, moving Alessandro Florenzi up.
The Derby della Capitale kicks off at 17.00 UK time (16.00 GMT), click here for a match preview.
Simone Inzaghi’s men are the favourites going in after their 3-0 victory away to Sampdoria, but they are also more consistent, having changed very little since last season’s Coppa Italia triumph.
The only new face in the starting XI is expected to be Lazzari, who already impressed on his debut after the move from SPAL.
Lucas Leiva has shaken off a knock to start with Sergej Milinkovic Savic and Luis Alberto, supporting strikers Joaquin Correa and Immobile.
Only Jordan Lukaku and Wallace are still on the treatment table.
Roma fumbled a lead three times in their 3-3 draw with Genoa and are still adapting to new Coach Paulo Fonseca.
The tactician tried to keep his picks close to his chest, confirming only that Diego Perotti and Leonardo Spinazzola were out injured.
It’s widely reported former Chelsea full-back Zappacosta will be given his first start, with Mancini partnering Federico Fazio at centre-back, sending Juan Jesus to the bench with new signing Chris Smalling.
Bryan Cristante should stave off competition from Amadou Diawara for the midfield alongside Lorenzo Pellegrini.
Cengiz Under and Nicolò Zaniolo are likely to be joined by Florenzi in the group supporting Edin Dzeko, as the versatile captain takes on another different role, replacing Justin Kluivert and injured Perotti.
In truth, it’s a return to his origins, as Florenzi was an attack-minded winger before the transformation to right-back.
Probable line-ups
Lazio (3-5-2): Strakosha; Luiz Felipe, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Correa, Immobile
Roma (4-2-3-1): Pau Lopez; Zappacosta, Mancini, Fazio, Kolarov; Cristante, Pellegrini; Under, Zaniolo, Florenzi; Dzeko