Joaquin Correa is the favourite to partner Ciro Immobile for Lazio, while Christian Eriksen could start with Romelu Lukaku and returning Lautaro Martinez for Inter.
It kicks off at the Stadio Olimpico at 19.45 GMT, click here for a match preview.
This is a Scudetto showdown, because Inter and Juventus are currently joint top of the Serie A table, with Lazio just one point behind.
Joaquin Correa is the favourite to partner Ciro Immobile for Lazio, while Christian Eriksen could start with Romelu Lukaku and returning Lautaro Martinez for Inter.
It kicks off at the Stadio Olimpico at 19.45 GMT, click here for a match preview.
This is a Scudetto showdown, because Inter and Juventus are currently joint top of the Serie A table, with Lazio just one point behind.
Depending on what Juve do against Brescia this afternoon, one of these teams could even be sole leaders by the end of the day.
Lazio must do without injured Senad Lulic for at least three weeks following ankle surgery, so Jony is the natural replacement on the left side of a five-man midfield, supporting Luis Alberto, Lucas Leiva and Sergej Milinkovic-Savic.
Felipe Caicedo has been regularly partnering Capocannoniere Immobile lately, but Correa has now fully recovered from his injury and is tipped to start.
As for the defence, Luiz Felipe and Patric are battling for the third slot alongside Francesco Acerbi and Stefan Radu.
Inter played on Wednesday evening in the 1-0 Coppa Italia semi-final home defeat to Napoli, so there is the risk of fatigue.
Lautaro Martinez makes his Serie A comeback after a two-match ban and will partner Romelu Lukaku, but there are quite a few question marks elsewhere for Antonio Conte.
Samir Handanovic is still out after suffering a hairline fracture to the little finger on his left hand, so Daniele Padelli is in goal once again.
Alessandro Bastoni’s ban has expired, so he should take over from Diego Godin, while Stefan de Vrij returns to the Olimpico for the first time as an opponent.
Christian Eriksen and Matias Vecino are in the running for a midfield spot, as Stefano Sensi, Roberto Gagliardini, Kwadwo Asamoah and Sebastiano Esposito are injured.
Ashley Young and Antonio Candreva are tipped to take the wing-back roles.
Probable line-ups
Lazio: Strakosha; Patric, Acerbi, Radu; Marusic, Milinkovic, Leiva, Luis Alberto, Jony; Correa, Immobile
Lazio bench: Proto, Guerrieri, Luiz Felipe, Bastos, Vavro, Lazzari, D. Anderson, Minala, Cataldi, Parolo, J Lukaku, A. Anderson, Caicedo, Adekanye
Inter: Padelli; Skriniar, de Vrij, Bastoni; Candreva, Barella, Brozovic, Eriksen, Young; R Lukaku, Lautaro Martinez
Inter bench: Handanovic, Berni, Stankovic, Godin, Ranocchia, D'Ambrosio, Biraghi, Moses, Borja Valero, Vecino, Sanchez
Ref: Rocchi