Mario Mandzukic has also reportedly sustained an injury, leaving Juventus with no centre-forwards against Lazio on Saturday.
It kicks off at 17.00 GMT, click here for a match preview.
The Bianconeri are already missing Gonzalo Higuain, Federico Bernardeschi and Juan Cuadrado from their attack, with only Pipita potentially able to play against Tottenham Hotspur in the Champions League on Wednesday.
Mario Mandzukic has also reportedly sustained an injury, leaving Juventus with no centre-forwards against Lazio on Saturday.
It kicks off at 17.00 GMT, click here for a match preview.
The Bianconeri are already missing Gonzalo Higuain, Federico Bernardeschi and Juan Cuadrado from their attack, with only Pipita potentially able to play against Tottenham Hotspur in the Champions League on Wednesday.
Mandzukic was due to start in Rome with support from Paulo Dybala and Douglas Costa in the trident attack.
However, there are reports that the Croatia international also had a slight problem in training on Friday and wouldn’t be risked ahead of the trip to Wembley.
If that is the case, then Alex Sandro would again be used on the left side of the trident, with Dybala turned into an atypical centre-forward.