Italy U21 have to cope without Matteo Lovato, Andrea Carboni and Lorenzo Pirola, who have left the squad ahead of the friendly against Romania.
The Azzurrini CT Paolo Nicolato has lost three vital players from the squad ahead of the match on Tuesday.
Atalanta centre-back Lovato has suffered a problem in the left thigh, according to SportItalia, while Cagliari defender Andrea Carboni has picked up an illness.
The 19-year-old centre-back Pirola returns to Serie B side Monza due to a knee injury.
Nicolato’s men picked up a 2-0 win over Republic of Ireland and are still unbeaten in Group 6 of the European U21 Championship Qualifiers.
Italy U21 sit one point behind Sweden, who are first in the table, but have one game in hand.
Republic of Ireland host Sweden on Tuesday and can give the Italians a helping hand in the battle for a place at the 2023 European U21 Championship in Georgia and Romania.