Milan ring the changes with Theo Hernandez, Ismael Bennacer and Rafael Leao, while Torino give Simone Verdi his first start.
It kicks off at 20.00 UK time (19.00 GMT). You can follow all the build-up and action as it happens on the LIVEBLOG.
Both teams are coming off heavy defeats and have struggled to perform so far this season, so another negative result here could be critical.
Milan ring the changes with Theo Hernandez, Ismael Bennacer and Rafael Leao, while Torino give Simone Verdi his first start.
It kicks off at 20.00 UK time (19.00 GMT). You can follow all the build-up and action as it happens on the LIVEBLOG.
Both teams are coming off heavy defeats and have struggled to perform so far this season, so another negative result here could be critical.
Marco Giampaolo makes changes after the 2-0 Derby della Madonnina defeat, as Davide Calabria returns from suspension and Theo Hernandez gets his first start in place of Ricardo Rodriguez at left-back.
Former Empoli midfielder Bennacer, who was Player of the Tournament at the Africa Cup of Nations for Algeria, is preferred to Lucas Biglia, while 20-year-old Portuguese striker Rafael Leao is again picked to partner Krzysztof Piatek.
Suso could be a trequartista, or more likely wide right in a 4-3-3 formation, as Lucas Paqueta and Mattia Caldara are injured.
Torino suffered back-to-back losses against Lecce and Sampdoria, so the pressure is on, especially as they crashed out of the Europa League play-offs to Wolves last month.
Cristian Ansaldi, Vittorio Parigini and Sasa Lukic are on the treatment table, but former Napoli talent Verdi gets his first start.
Verdi is a versatile creative midfielder who started out in the Milan youth academy.
It was reported he’d be used with Alex Berenguer in support of Andrea Belotti, but instead Simone Zaza also plays in a more attack-minded line-up.
Ola Aina is moved on to the left rather than ex-Milan winger Diego Laxalt.
The defence is revamped yet again, with Armando Izzo, Lyanco and Bremer.
Torino: Sirigu; Izzo, Lyanco, Bremer; De Silvestri, Baselli, Rincon, Ola Aina; Verdi; Zaza, Belotti
Torino bench: Ujkani, Rosati, Iago Falque, Bonifazi, Ansaldi, Edera, Berenguer, Millico, Meite, Djidji, Nkoulou, Laxalt
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Theo Hernandez; Kessie, Bennacer, Calhanoglu; Suso, Piatek, Leao
Milan bench: A Donnarumma, Reina, Conti, Duarte, Gabbia, Rodriguez, Biglia, Bonaventura, Krunic, Borini, Castillejo, Rebic