Cristiano Ronaldo experiences his first Derby della Mole with Paulo Dybala, Mario Mandzukic and Emre Can for Juventus, while Torino have Simone Zaza and Andrea Belotti.
It kicks off at the Stadio Olimpico Grande Torino at 19.30 GMT.
You can follow the build-up and action as it happens from this game and Inter v Udinese on the LIVEBLOG.
This has always been one of the highlights of the Calcio calendar and a fiery local rivalry.
Cristiano Ronaldo experiences his first Derby della Mole with Paulo Dybala, Mario Mandzukic and Emre Can for Juventus, while Torino have Simone Zaza and Andrea Belotti.
It kicks off at the Stadio Olimpico Grande Torino at 19.30 GMT.
This has always been one of the highlights of the Calcio calendar and a fiery local rivalry.
Leaders Juventus have dropped points only once in Serie A this season, against Genoa, and want to make up for the midweek Champions League defeat to Young Boys.
Rodrigo Bentancur has been a regular in recent weeks, but he is suspended, with Sami Khedira, Joao Cancelo and Juan Cuadrado injured.
Mattia De Sciglio and Alex Sandro are therefore the full-backs, with Giorgio Chiellini returning from his midweek rest to partner Leonardo Bonucci.
Emre Can is in the starting XI for the first time since undergoing surgery to remove nodules from his thyroid in October.
Paulo Dybala supports Mandzukic and Cristiano Ronaldo, the Portuguese star experiencing his first Derby della Mole after Manchester and Madrid editions.
Torino are fighting for a Europa League place and on a very positive run of form under Coach Walter Mazzarri.
Iago Falque was the only real injury doubt in the build-up and he failed a fitness test, so Simone Zaza starts alongside Andrea ‘Il Gallo’ Belotti.
Juve have lost only one of their last 12 Serie A visits to the Granata side of town, drawing two and winning the other nine.
The Bianconeri are unbeaten on their Serie A travels since Sampdoria in November 2017, managing 17 wins and three stalemates.
Torino: Sirigu; Izzo, Nkoulou, Djidji; Aina, Meite, Rincon, Baselli, Ansaldi; Zaza, Belotti
Torino bench: Ichazo, Rosati, Lyanco, Soriano, Lukic, Damascan, Edea, Berenguer, Moretti, Parigini, De Silvestri, Bremer
Juventus: Perin; De Sciglio, Bonucci, Chiellini, Alex Sandro; Emre Can, Pjanic, Matuidi; Dybala; Ronaldo, Mandzukic
Juventus bench: Szczesny, Pinsoglio, Benatia, Douglas Costa, Kean, Rugani, Bernardeschi, Spinazzola
Ref: Guida