Torino and Fiorentina are forced into radical changes, as Simone Zaza and Federico Chiesa lead the way.
It kicks off at the Stadio Olimpico Grande Torino at 14.00 GMT.
You can follow the build-up and action as it happens from all today’s Serie A games on the LIVEBLOG.
These two teams are both in crisis, with coaches Walter Mazzarri and Vincenzo Montella hanging by a thread.
Torino and Fiorentina are forced into radical changes, as Simone Zaza and Federico Chiesa lead the way.
It kicks off at the Stadio Olimpico Grande Torino at 14.00 GMT.
You can follow the build-up and action as it happens from all today’s Serie A games on the LIVEBLOG.
These two teams are both in crisis, with coaches Walter Mazzarri and Vincenzo Montella hanging by a thread.
That makes it all the more frustrating that they face off without many of their star names available.
Andrea Belotti, Iago Falque, Vincenzo Millico, Lyanco and Sasa Lukic are injured for Toro, with Simone Edera suspended.
It leaves precious few options in attack, so Simone Zaza is brought back into the fold with support from Simone Verdi and Alex Berenguer.
Fiorentina have Federico Chiesa back from the start after his muscular problems, and he is certainly needed, because Franck Ribery, Kevin-Prince Boateng and captain German Pezzella are on the treatment table.
It means teenage forward Dusan Vlahovic starts again, as the Viola desperately try to stop the rot of three consecutive defeats, failing to score in the last two.
There is a statistic that might help boost their confidence, because over the last two seasons, Fiorentina have won 26 per cent of the Serie A games with Chiesa in the starting XI, compared to not a single victory in his absence (D3 L3).
Torino: Sirigu; Izzo, Nkoulou, Bremer; De Silvestri, Baselli, Rincon, Ansaldi; Verdi, Berenguer; Zaza
Fiorentina: Dragowski; Milenkovic, Ceccherini, Caceres; Ghezzal, Benassi, Pulgar, Castrovilli, Dalbert; Chiesa, Vlahovic
Ref: Giacomelli