Napoli go into a head-to-head battle with joint Europa League group leaders Sparta Prague, starting almost an ideal XI.
It kicks off at 18.00 GMT and finds both teams paired on nine points, followed by Young Boys on six.
The Partenopei fought back from an early goal to win this fixture 3-1 at the San Paolo in September.
Sparta have won all five of their Europa home fixtures this season, including the preliminary rounds, whereas Napoli have just one victory in their last six continental trips.
Napoli go into a head-to-head battle with joint Europa League group leaders Sparta Prague, starting almost an ideal XI.
It kicks off at 18.00 GMT and finds both teams paired on nine points, followed by Young Boys on six.
The Partenopei fought back from an early goal to win this fixture 3-1 at the San Paolo in September.
Sparta have won all five of their Europa home fixtures this season, including the preliminary rounds, whereas Napoli have just one victory in their last six continental trips.
Dries Mertens is still out after being knocked unconscious a week ago for Belgium, while Lorenzo Insigne, Michu and Juan Camilo Zuniga are also on the treatment table.
Jonathan de Guzman was expected to start, but Gonzalo Higuain, Marek Hamsik and Jose Callejon all play with Jorginho in a more advanced trequartista role.
The only real changes are in the full-back positions, where Giandomenico Mesto and Miguel Angel Britos step in.
Sparta Prague confirm their usual line-up, including top scorer Lafata in attack.
Only two Italian clubs have ever beaten Sparta in Prague – Milan in 1973 and Lazio in 2000 – along with five draws and three defeats.
Sparta Prague: Stech; Kaderabek, Brabec, Holek, Nhamoinesu; Husbauer, Mareček, Matejovsky; Dočkal, Lafata, Krejci
Sparta bench: Vorel, Pamic, Svejdik, Kovac, Vacek, Pnkryl, Schick
Napoli: Rafael; Mesto, Albiol, Koulibaly, Britos; Gargano, David Lopez; Callejon, Jorginho, Hamsik; Higuain
Napoli bench: Andujar, Henrique, Maggio, Ghoulam, De Guzman, Inler, Zapata