Roma are desperate for a result at Sassuolo to both close on Lazio in second and keep Napoli behind them in fourth place.
It kicks off at 19.45 UK time (18.45 GMT), follow all eight of tonight’s games on our LIVEBLOG.
Rudi Garcia is under increasing pressure, as in the space of two months the Scudetto challenge has given way to a fierce battle just to qualify for the Champions League.
They go into this round one point behind Lazio and only two in front of Napoli.
Roma are desperate for a result at Sassuolo to both close on Lazio in second and keep Napoli behind them in fourth place.
It kicks off at 19.45 UK time (18.45 GMT), follow all eight of tonight’s games on our LIVEBLOG.
Rudi Garcia is under increasing pressure, as in the space of two months the Scudetto challenge has given way to a fierce battle just to qualify for the Champions League.
They go into this round one point behind Lazio and only two in front of Napoli.
Jose Holebas joins Douglas Maicon, Leandro Castan and Kevin Strootman on the injury list.
Francesco Totti is dropped, moving Miralem Pjanic to a trequartista role behind rapid strikers Gervinho and Victor Ibarbo.
However, Seydou Keita picked up an injury in the warm-up and was replaced by striker Seydou Doumbia.
This returned Roma to their more traditional tactic with Pjanic in midfield.
Sassuolo have lost seven of the last 10 rounds, but did enough earlier in the season to secure their Serie A status.
Top scorer Domenico Berardi is suspended, so ex-Lazio striker Antonio Floro Flores steps into the trident with Sergio Floccari and Nicola Sansone, resting Simone Zaza.
Absentees include Emanuele Terranova, Luca Antei, Francesco Magnanelli and Sime Vrsaljko.
It’s a special game for Coach Eusebio Di Francesco, who spent much of his career in the Roma midfield and was team-mates with Francesco Totti.
Earlier this season Sassuolo were 2-0 up at the Stadio Olimpico, but threw it away for a 2-2 draw.
Sassuolo: Consigli; Acerbi, Cannavaro, Peluso; Taider, Brighi, Missiroli, Longhi; Sansone, Floccari, Floro Flores
Roma: De Sanctis; Florenzi, Manolas, Astori, Torosidis; Keita, De Rossi, Pjanic, Nainggolan; Ibarbo, Doumbia, Gervinho