Udinese surprisingly drop Antonio Di Natale and Manolo Gabbiadini starts possibly his last Sampdoria game.
It kicks off at 14.00 GMT, click here for a match preview.
The Blucerchiati are determined to end 2014 on a high after a remarkable year under Sinisa Mihajlovic.
They are challenging for third place, held leaders Juventus to a 1-1 draw in Turin last week and have lost only once all season.
Udinese surprisingly drop Antonio Di Natale and Manolo Gabbiadini starts possibly his last Sampdoria game.
It kicks off at 14.00 GMT, click here for a match preview.
The Blucerchiati are determined to end 2014 on a high after a remarkable year under Sinisa Mihajlovic.
They are challenging for third place, held leaders Juventus to a 1-1 draw in Turin last week and have lost only once all season.
On the other hand, Udinese are deeply inconsistent, able to beat Inter at San Siro and lose at home to Genoa.
Alessio Romagnoli and Allan sit out bans, while Matias Silvestre, Pawel Wszolek, Luis Muriel and Maurizio Domizzi are sidelined.
In a surprise move, Coach Andrea Stramaccioni has left veteran hitman Di Natale out of the starting XI, favouring young Spanish striker Alexandre Geijo and Frenchman Cyril Thereau.
Gabbiadini starts probably his final game for Samp, as he’s due to join Napoli in January.
Sampdoria: Romero; De Silvestri, Gastaldello, Regini, Mesbah; Soriano, Palombo, Obiang; Gabbiadini, Okaka, Eder
Sampdoria bench: Da Costa, Viviano, Duncan, Fedato, Krsticic, Bergessio, Rizzo, Marchionni, Fornasier, Cacciatore
Udinese: Karnezis; Heurtaux, Danilo, Wague; Widmer, Badu, Pinzi, Kone, Pasquale; Thereau, Geijo
Udinese bench: Brkic, Scuffet, Bruno Fernandes, Di Natale, Zapata, Belmonte, Bubnjic, Guilherme, Hallberg, Gabriel Silva, Lucas Evangelista