Inter need to recover from their 4-1 thrashing by Fiorentina, but Roberto Mancini faces his past in Sampdoria and Walter Zenga.
It kicks off at 14.00 UK time (13.00 GMT), follow the action from all the Serie A games on our LIVEBLOG.
The Nerazzurri remain joint top of the table, but their perfect Serie A start was shattered by a 4-1 home defeat to Fiorentina last Sunday.
Inter need to recover from their 4-1 thrashing by Fiorentina, but Roberto Mancini faces his past in Sampdoria and Walter Zenga.
It kicks off at 14.00 UK time (13.00 GMT), follow the action from all the Serie A games on our LIVEBLOG.
The Nerazzurri remain joint top of the table, but their perfect Serie A start was shattered by a 4-1 home defeat to Fiorentina last Sunday.
Mancini was bullish and irritable in his Press conference, arguing the result was “absurd” and “until the dismissal it was our best performance of the season” – a view shared by very few even within the Inter community.
Joao Miranda was sent off and is therefore suspended, while Stevan Jovetic and Dodo are sidelined.
Rodrigo Palacio joins Ivan Perisic and Mauro Icardi in a 4-3-2-1 formation, as the three-man defence is shelved straight away.
Sampdoria were beaten by Atalanta on Monday, but can still boast a 100 per cent record on home turf.
Current Capocannoniere Eder leads the way, having scored six goals in as many games, supported by Luis Muriel and Joaquin Correa.
Andrea Coda, Mattia Cassani, Lorenzo De Silvestri, Matias Silvestre and Lazaros Christodoulopoulos are all out of action, but Antonio Cassano could come off the bench.
It’s a special reunion for the Coaches, as Zenga and Mancini were teammates at Sampdoria in the 1990s.
Zenga went on to have a lengthy career as Inter goalkeeper and confirmed “this game cannot be like the others for me.”
Sampdoria: Viviano; Pereira, Moisander, Zukanovic, Mesbah; Soriano, Fernando, Barreto; Correa; Muriel, Eder
Sampdoria bench: Puggioni, Brignoli, Rodriguez, Palombo, Regini, Carbonero, Rocca, Ivan, Cassano
Inter: Handanovic; Santon, Medel, Murillo, Telles; Guarin, Melo, Kondogbia; Perisic, Palacio; Icardi
Inter bench: Carrizo, Berni, Juan Jesus, Biabiany, Montoya, Ljajic, Ranocchia, Gnoukouri, D’Ambrosio, Nagatomo, Brozovic, Manaj