Both Roma and Palermo are in desperate need of a victory after recent setbacks, but Rudi Garcia has to reshuffle his pack.
It kicks off at the Stadio Barbera in Sicily at 14.00 UK time (13.00 GMT), follow the action from all the Serie A games on our LIVEBLOG.
The Giallorossi are inconsistency personified, as they can crush Carpi 5-1 and a few days later be humiliated 3-2 by BATE Borisov in the Champions League.
Both Roma and Palermo are in desperate need of a victory after recent setbacks, but Rudi Garcia has to reshuffle his pack.
It kicks off at the Stadio Barbera in Sicily at 14.00 UK time (13.00 GMT), follow the action from all the Serie A games on our LIVEBLOG.
The Giallorossi are inconsistency personified, as they can crush Carpi 5-1 and a few days later be humiliated 3-2 by BATE Borisov in the Champions League.
Although there was a late fightback, they were 3-0 down after 31 minutes in Belarus, adding fuel to rumours Garcia could be set for the axe.
He has numerous injury problems to contend with, missing Francesco Totti, Edin Dzeko, Seydou Keita, Antonio Rudiger and Kevin Strootman.
Daniele De Rossi is therefore again re-routed to central defence with Alessandro Florenzi put back into a midfield role.
Mohamed Salah has scored in each of his last three Serie A games and hopes to keep that trend going, joined by Gervinho and Iago Falque.
Palermo had started the campaign strongly, but are now coming off three consecutive defeats and the pressure is building on Coach Beppe Iachini.
Michel Morganella, Francesco Bolzoni and Uros Djurdjevic are all out of action.
Franco Vazquez starts, but Alberto Gilardino is benched again. Watch out for Swedish Under-21 international Oscar Hiljemark.
Roma have a poor record against Palermo, picking up just one point in their last three Serie A meetings, home and away.
Palermo: Sorrentino; Struna, Gonzalez, El Kaoutari, Lazaar; Rigoni, Jajalo, Chochev; Hiljemark; Trajkovski, Vazquez
Palermo bench: Colombi, Vitiello, Rispoli, Andelkovic, Goldaniga, Cassini, Gilardino, Brugman, Quaison, Maresca, Daprela, La Gumina
Roma: Szczesny; Torosidis, Manolas, De Rossi, Digne; Florenzi, Nainggolan, Pjanic; Salah, Gervinho, Iago Falque
Roma: De Sanctis, Castan, Iturbe, Maicon, Ponce, Vainqueur, Gyomber, Emerson, Ucan, Machin, Sadiq, Nura