Stephan El Shaarawy supports Edin Dzeko and Henrikh Mkhitaryan, while Lazio rely on Ciro Immobile, Vedat Muriqi and returning Sergej Milinkovic-Savic.
It kicks off at 19.45 UK time (18.45 GMT).
Stephan El Shaarawy supports Edin Dzeko and Henrikh Mkhitaryan, while Lazio rely on Ciro Immobile, Vedat Muriqi and returning Sergej Milinkovic-Savic.
It kicks off at 19.45 UK time (18.45 GMT).
The Derby della Capitale is always a tense affair regardless of motivation, but here finds Roma in seventh and Lazio in sixth, both at risk of missing their European targets.
The Biancocelesti are still technically in contention for the top four, as they have a game in hand against Torino to be played midweek, but just about scraped a 1-0 win over Parma on Wednesday thanks to a last-gasp Immobile goal.
There are several changes from that game, as Milinkovic-Savic returns after surgery on a broken nose, while Lucas Leiva and Andreas Pereira are back from their bans.
However, Joaquin Correa and Felipe Caicedo are not 100 per cent fit, so Vedat Muriqi partners Ciro Immobile.
Roma’s injury crisis remains extensive, missing the likes of Jordan Veretout, Pau Lopez, Chris Smalling, Leonardo Spinazzola, Amadou Diawara, Carles Perez, Riccardo Calafiori and Nicolò Zaniolo.
El Shaarawy is back in the starting XI after a long injury lay-off, with Henrikh Mkhitaryan and Lorenzo Pellegrini behind Dzeko.
It’s Paulo Fonseca’s last chance to win a Rome Derby before he hands over to Jose Mourinho.
Roma sold 46,000 ‘virtual’ tickets to the derby for €2 each, with all the money going to charity.
Roma: Fuzato; Karsdorp, Mancini, Ibanez, Peres; Cristante, Darboe; Mkhitaryan, Pellegrini, El Shaarawy; Dzeko
Lazio: Reina; Marusic, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Immobile, Muriqi
Ref: Pairetto