Roma rely on Edin Dzeko, Pedro and Henrikh Mkhitaryan, while Fiorentina use Franck Ribery and Jose Callejon together in attack.
It kicks off at 17.00 GMT, follow all the build-up and action as it happens on the LIVEBLOG.
Roma rely on Edin Dzeko, Pedro and Henrikh Mkhitaryan, while Fiorentina use Franck Ribery and Jose Callejon together in attack.
It kicks off at 17.00 GMT, follow all the build-up and action as it happens on the LIVEBLOG.
There are more injury problems for the Giallorossi after their disappointing 0-0 Europa League draw with CSKA Sofia, missing Davide Santon, Amadou Diawara, Javier Pastore, Nicolò Zaniolo and Riccardo Calafiori.
Chris Smalling made his first start on Thursday after a muscular problem and is in the XI again this evening, sending Marash Kumbulla to the bench.
Fiorentina are struggling too so far this term, missing Borja Valero with German Pezzella not fully fit either.
Lucas Martinez Quarta therefore gets his first start in defence, but the big news is an all-new veteran front two of Franck Ribery and Jose Callejon, neither of whom are technically strikers.
Roma: Mirante; Mancini, Smalling, Ibanez; Karsdorp, Veretout, Pellegrini, Spinazzola; Pedro, Mkhitaryan; Dzeko
Fiorentina: Dragowski; Martinez Quarta, Milenkovic, Caceres; Lirola, Bonaventura, Amrabat, Castrovilli, Biraghi; Callejon, Ribery
Ref: Orsato