Simone Inzaghi makes his debut on the Lazio bench in a tricky trip to desperate Palermo, who have to reshuffle.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
This has been a tumultuous week for Lazio, who lost the Rome Derby 4-1 to their bitter rivals and sacked Coach Stefano Pioli.
Simone Inzaghi makes his debut on the Lazio bench in a tricky trip to desperate Palermo, who have to reshuffle.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
This has been a tumultuous week for Lazio, who lost the Rome Derby 4-1 to their bitter rivals and sacked Coach Stefano Pioli.
Former player Inzaghi – younger brother of ex-Milan boss Pippo – gets his Serie A debut as a tactician after working for several years in the Lazio youth academy.
He has Sergej Milinkovic-Savic back in the squad, albeit only fit enough for the bench, and is missing Stefano Mauri, Etrit Berisha, Abdoullay Konko, Edson Braafheid, Dusan Basta, Stefan Radu, Ricardo Kishna and Stefan de Vrij.
Wesley Hoedt also sits out a ban, but Senad Lulic returns from suspension in defence.
Palermo are in the bottom three, but a point here would take them back above Carpi and into the safety zone.
There’s a huge problem for Coach Walter Novellino, as star player Franco Vazquez is suspended.
Edoardo Goldaniga is also injured in defence, so Alberto Gilardino partners Robin Quaison in a new 4-4-2 system.
It ended 1-1 when these sides met in November and Palermo haven’t beaten Lazio since a 5-1 hammering here in February 2012, earning two draws and three defeats.
Last season the Aquile ran out 4-0 winners at the Stadio Barbera with a Filip Djordjevic hat-trick.
Palermo: Sorrentino; Struna, Gonzalez, Andelkovic, Pezzella; Morganella, Hiljemark, Jajalo, Lazaar; Quaison; Gilardino
Palermo bench: Posavec, Alastra, Vitiello, Cionek, Rispoli, Chochev, Maresca, Brugman, Trajkovski, Balogh, La Gumina
Lazio: Marchetti; Patric, Bisevac, Gentiletti, Lulic; Parolo, Biglia, Onazi; Candreva, Klose, Keita Balde Diao
Lazio bench: Guerrieri, Matosevic, Mauricio, Mattia, Germoni, Murgia, Cataldi, Milinkovic-Savic, Djordjevic, Felipe Anderson, Matri