Paulo Dybala returns to face his former club with Alvaro Morata dropped again as Juventus visit Palermo.
It kicks off at the Stadio Barbera at 19.45 GMT, follow the action as it happens on our LIVEBLOG.
This is an emotional moment for Dybala, who first joined Palermo as a teenager and was groomed to become a €32m signing.
Paulo Dybala returns to face his former club with Alvaro Morata dropped again as Juventus visit Palermo.
It kicks off at the Stadio Barbera at 19.45 GMT, follow the action as it happens on our LIVEBLOG.
This is an emotional moment for Dybala, who first joined Palermo as a teenager and was groomed to become a €32m signing.
He will face off for the first time against his former strike partner Franco Vazquez, who has been linked with a potential reunion in Turin next season.
Max Allegri caused controversy when dropping Morata for Mario Mandzukic against Manchester City midweek, but it worked as the Croatian scored the winning Champions League goal.
He once again leaves Morata on the bench in favour of Mandzukic in a 3-5-2 system with Juan Cuadrado and Patrice Evra stepping in for Stephan Lichtsteiner and Alex Sandro.
Sami Khedira, Hernanes, Roberto Pereyra, Mario Lemina, Martin Caceres and Kwadwo Asamoah are all unavailable.
Paul Pogba has to be careful, as he is one yellow card away from a ban and Juve face Lazio next week.
Palermo picked up a 1-1 draw away to Lazio on Coach Davide Ballardini’s debut and hope to continue building under his guidance.
Roberto Vitiello, Michel Morganella, Francesco Bolzoni and Uros Djurdjevic are on the treatment table.
The biggest change since Beppe Iachini’s dismissal is the introduction of Gaston Brugman as a trequartista behind Vazquez and Alberto Gilardino.
Defender Edoardo Goldaniga scored on his full Serie A debut last week and was sold to Palermo as part of the Dybala deal.
Juve are unbeaten at the Barbera since a 2-1 result in February 2011, but the last stalemate in this fixture was all the way back in 1969.
The Bianconeri had struggled in Serie A, but are here seeking a fourth consecutive victory.
Palermo: Sorrentino; Struna, Goldaniga, Gonzalez, Lazaar; Hiljemark, Jajalo, Chochev; Brugman; Vazquez, Gilardino
Palermo bench: Colombi, Alastra, El Kaoutari, Rispoli, Daprelà, Andelkovic, Maresca, Quaison, Trajkovski
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Cuadrado, Sturaro, Marchisio, Pogba, Evra; Mandzukic, Dybala
Juventus bench: Neto, Rubinho, Lichtsteiner, Rugani, Alex Sandro, Padoin, Vitale, Zaza, Morata