Dries Mertens, Lorenzo Insigne and Matteo Politano host Ciro Immobile, Luis Alberto and Sergej Milinkovic-Savic, as Napoli and Lazio go head-to-head for fifth place.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens from this game and Roma–Atalanta on the LIVEBLOG.
Dries Mertens, Lorenzo Insigne and Matteo Politano host Ciro Immobile, Luis Alberto and Sergej Milinkovic-Savic, as Napoli and Lazio go head-to-head for fifth place.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time (18.45 GMT).
There are only two points separating these teams going in, although Lazio have a game in hand to be played against Torino.
Diego Demme is suspended for Napoli, so Tiemoue Bakayoko gets a rare start before he returns to Chelsea at the end of his loan spell.
David Ospina and Faouzi Ghoulam are still out of action, but Hirving Lozano returns from his ban.
Mertens gets the nod upfront rather than Victor Osimhen.
Lazio had one big concern going into the game, as Luis Alberto has a bruised ankle, but he is passed fit to start.
Joaquin Correa and Milinkovic-Savic support hitman and native Neapolitan Ciro Immobile.
It’s a return to Naples for Pepe Reina, who remains beloved by the fans here.
Coach Simone Inzaghi is again still self-isolating at home after his family tested positive for COVID-19.
Napoli: Meret; Di Lorenzo, Koulibaly, Manolas, Hysaj; Fabian Ruiz, Bakayoko; Politano, Zielinski, L Insigne; Mertens
Napoli bench: Contini, Idasiak, Zezadka, Mario Rui, Elmas, Osimhen, Lozano, Maksimovic, Rrahmani, Petagna, Cioffi, Lobotka
Lazio: Reina; Marusic, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Fares; Immobile, Correa
Lazio bench: Strakosha, Patric, Pereira, Armini, Hoedt, Parolo, Lulic, Caicedo, Cataldi, Musacchio, Akpa Akpro, Muriqi
Ref: Di Bello