Napoli are decimated and in the midst of a crisis, but have Victor Osimhen back in the starting XI against Cristiano Ronaldo and Alvaro Morata’s Juventus.
It kicks off at the Stadio Diego Armando Maradona at 17.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
Napoli are decimated and in the midst of a crisis, but have Victor Osimhen back in the starting XI against Cristiano Ronaldo and Alvaro Morata’s Juventus.
It kicks off at the Stadio Diego Armando Maradona at 17.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is the first Serie A meeting between the clubs this season, because the October encounter was called off due to COVID cases.
Because of their decision not to travel to Turin, Napoli were initially docked a point and given an automatic 3-0 defeat, but that was overturned on appeal.
There is still no date for when that game will be rescheduled, but they did meet in the Supercoppa last month, Juventus winning 2-0 after Lorenzo Insigne missed a penalty.
Gennaro Gattuso remains under intense pressure following a series of poor results, but has a severely weakened team, missing injured Dries Mertens, Kalidou Koulibaly, Kostas Manolas, Diego Demme, Elseid Hysaj and Faouzi Ghoulam.
The only positive is Osimhen’s first Serie A start since November, supported by Lorenzo Insigne in a more central role, Matteo Politano and Hirving Lozano.
Juventus qualified for the Coppa Italia Final after the midweek 0-0 draw with Inter, having won the first leg, and their confidence is sky high, particularly in defence.
Paulo Dybala was joined by Aaron Ramsey and Arthur on the treatment table, so Federico Chiesa, Federico Bernardeschi, Morata and Ronaldo lead the way.
Giorgio Chiellini celebrates his 400th Serie A appearance and hopes Juve keep a fourth consecutive league clean sheet, but Leonardo Bonucci is not fully fit.
Napoli: Ospina; Di Lorenzo, Maksimovic, Rrahmani, Mario Rui; Bakayoko, Zielinski; Politano, L Insigne, Lozano; Osimhen
Napoli bench: Meret, Contini, Zedadka, Elmas, Fabian Ruiz, Petagna, Costanzo, Cioffi, Lobotka
Juventus: Szczesny; Cuadrado, De Ligt, Chiellini, Danilo; Chiesa, Bentancur, Rabiot, Bernardeschi; Morata, Ronaldo
Juventus bench: Pinsoglio, Buffon, Alex Sandro, McKennie, Bonucci, Demiral, Di Pardo, Frabotta, Fagioli, Kulusevski, Peeters
Ref: Doveri