Napoli could well be facing their future, as Sinisa Mihajlovic’s Sampdoria visit the San Paolo in a European showdown.
It kicks off at 19.45 UK time (18.45 GMT), click here to follow our LIVEBLOG.
The Partenopei have the opportunity to close within two points of Roma in third place and three of Lazio in second, so Champions League qualification is still very much up for grabs.
Napoli could well be facing their future, as Sinisa Mihajlovic’s Sampdoria visit the San Paolo in a European showdown.
It kicks off at 19.45 UK time (18.45 GMT), click here to follow our LIVEBLOG.
The Partenopei have the opportunity to close within two points of Roma in third place and three of Lazio in second, so Champions League qualification is still very much up for grabs.
They’ve already gone through to the Europa League semi-finals, where they will face Dnipro next month.
Christian Maggio is suspended, joining Jonathan de Guzman, Juan Camilo Zuniga and Michu in the stands.
Despite playing a 2-2 draw with Wolfsburg on Thursday night, Rafa Benitez keeps squad rotation to a minimum.
The big news is that ex-Sampdoria star Manolo Gabbiadini starts against his former club along with Lorenzo Insigne and Gonzalo Higuain.
Sampdoria have been one of the surprise packages of the campaign and that earned Coach Mihajlovic links with the Napoli bench next season.
He tried out the system with all four strikers last week, but it only resulted in a 0-0 draw against Cesena, so Samp go back to the 4-2-3-1 approach.
It’s still very attack-minded with Eder, Roberto Soriano, Samuel Eto’o and Stefano Okaka together.
Luis Muriel is ready to come off the bench.
Napoli: Andujar; Henrique, Albiol, Britos, Ghoulam; Jorginho, David Lopez; Callejon, Gabbiadini, Insigne; Higuain
Sampdoria: Viviano; De Silvestri, Silvestre, Romagnoli, Mesbah; Palombo, Obiang; Eder, Soriano, Eto'o; Okaka