Napoli and Roma go head-to-head with all-attack teams in this Scudetto showdown at the Stadio San Paolo, including Gonzalo Higuain v Edin Dzeko.
It kicks off at 17.00 GMT, follow the build-up and action as it happens on our LIVEBLOG.
This fixture holds a bitter rivalry and is also known as the Derby del Sole – the derby of the sun.
Napoli and Roma go head-to-head with all-attack teams in this Scudetto showdown at the Stadio San Paolo, including Gonzalo Higuain v Edin Dzeko.
It kicks off at 17.00 GMT, follow the build-up and action as it happens on our LIVEBLOG.
This fixture holds a bitter rivalry and is also known as the Derby del Sole – the derby of the sun.
They go into this game with very different moods, as Roma are without a victory in five competitive games, scraping just three draws, and were booed off the pitch by their own fans despite reaching the Champions League Round of 16 with a 0-0 against BATE Borisov.
Napoli have lost only one of their last 20 competitive matches, 3-2 at Bologna a week ago, along with 15 wins, scoring 49 goals and conceding 13.
Francesco Totti, Vasilis Torosidis and Kevin Strootman are injured for the visitors, while Gervinho is not even fit enough for the bench after a recurring muscular problem.
Mohamed Salah starts with centre-forward Dzeko and Iago Falque, returning Alessandro Florenzi to the right-back role.
Napoli miss only Manolo Gabbiadini, choosing Jose Callejon rather than Dries Mertens to complete the trident with Higuain and Lorenzo Insigne.
Roma’s last victory at the San Paolo was 3-1 in December 2011, followed by four consecutive defeats between Serie A and Coppa Italia, scoring once and conceding 10.
Napoli: Reina; Hysaj, Albiol, Koulibaly, Ghoulam; Allan, Jorginho, Hamsik; Callejon, Higuain, Insigne
Napoli bench: Gabriel, Rafael, Henrique, Strinic, Chiriches, Maggio, Chalobah, David Lopez, Valdifiori, Dezi, El Kaddouri, Mertens
Roma: Szczesny; Florenzi, Manolas, Rudiger, Digne; Nainggolan, De Rossi, Pjanic; Iago Falque, Dzeko, Salah
Roma bench: De Sanctis, Lobont, Emerson, Castan, Gyomber, Maicon, Keita, Ucan, Vainqueur, Iturbe, Sadiq