Dries Mertens leads the way as Napoli host struggling Pescara, who held them to a thrilling 2-2 draw in August.
It kicks off at 14.00 GMT, follow the build-up and action from all today's Serie A games on the Liveblog.
Maurizio Sarri’s men have started 2017 on the right foot, albeit with a few stutters, as they needed a last-gasp Lorenzo Tonelli goal to beat 10-man Sampdoria.
Dries Mertens leads the way as Napoli host struggling Pescara, who held them to a thrilling 2-2 draw in August.
It kicks off at 14.00 GMT, follow the build-up and action from all today's Serie A games on the Liveblog.
Maurizio Sarri’s men have started 2017 on the right foot, albeit with a few stutters, as they needed a last-gasp Lorenzo Tonelli goal to beat 10-man Sampdoria.
Midweek they also had more trouble than expected to defeat Spezia 3-1 in the Coppa Italia.
Raul Albiol returns from suspension, but Kalidou Koulibaly, Faouzi Ghoulam and Omar El Kaddouri are at the Africa Cup of Nations.
Vlad Chiriches is ruled out by injury and Ivan Strinic not 100 per cent fit.
Pescara are in the bottom three and look like strong candidates for relegation straight back into Serie B, having struggled to show much of the exciting football that got them promoted via the play-offs.
Coach Massimo Oddo had started so well, taking a 2-0 lead over Napoli in the opening round, only for Mertens to come off the bench and claw back a 2-2 draw.
Cristiano Briaghi is suspended with Simone Pepe, Norbert Gyomber, Hugo Campagnaro, Davide Vitturini, Francesco Zampano, Gaston Brugman and Jean-Christophe Bahebeck injured.
Guglielmo Stendardo added to the crisis today when waking up with flu symptoms, so Zuparic – who wasn't originally in the travelling party – has to start.
New signing Alberto Gilardino starts just days after his move from Empoli.
Pescara have never won at the Stadio San Paolo in Serie A, managing a single draw from six visits, scoring four goals and conceding 24.
Napoli: Reina; Hysaj, Albiol, Tonelli, Strinic; Zielinski, Jorginho, Hamsik; Callejon, Mertens, Insigne
Pescara: Bizzarri; Crescenzi, Coda, Zuparic; Verre, Bruno, Cristante, Memushaj; Caprari, Gilardino, Benali