This is the biggest game of the season, as new leaders Inter start Christian Eriksen with Romelu Lukaku against a Milan side one point behind using Zlatan Ibrahimovic and Hakan Calhanoglu.
It kicks off at 14.00 GMT at the Stadio Giuseppe Meazza, also known commonly as San Siro.
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is the biggest game of the season, as new leaders Inter start Christian Eriksen with Romelu Lukaku against a Milan side one point behind using Zlatan Ibrahimovic and Hakan Calhanoglu.
It kicks off at 14.00 GMT at the Stadio Giuseppe Meazza, also known commonly as San Siro.
You can follow all the build-up and action as it happens on the LIVEBLOG.
There is just one point separating these giants at the top of the table, as last week’s defeat at Spezia saw Milan lose the leadership for the first time this season.
It is played behind closed doors, yet for hours before kick-off there were over 4,000 fans outside San Siro representing both clubs, singing and waving their flags.
Ismael Bennacer and Mario Mandzukic are out after picking up injuries in Thursday’s 2-2 Europa League draw with Red Star Belgrade, so Sandro Tonali steps in with Ante Rebic, Hakan Calhanoglu and Alexis Saelemaekers supporting Ibrahimovic.
That means Rafael Leao is initially at least left on the bench.
It’s a special game for Gianluigi Donnarumma, his 200th in Serie A, despite the fact he’s not yet 22 years old.
Inter miss only Stefano Sensi with another muscular issue, but Arturo Vidal isn’t ready to start after a knock to the knee that also ruled him out of last week’s 3-1 win over Lazio.
Christian Eriksen therefore gets the nod in midfield with Marcelo Brozovic and Nicolò Barella, while Achraf Hakimi and Ivan Perisic take the wings.
Lautaro Martinez stands by Romelu Lukaku, the Belgian centre-forward having scored in his last three Serie A editions of the Derby della Madonnina.
He also found the net – and clashed with Ibrahimovic – in the Coppa Italia quarter-final last month, when Inter won 2-1 in stoppages through an Eriksen free kick after Zlatan had been sent off.
This is the first time the Milan Derby has been played with both clubs in the top two since April 2011.
The Rossoneri won 3-0 that time and went on to celebrate their most recent Scudetto.
There will be a minute's silence before kick-off for former Inter and Bologna defender Mauro Bellugi, who died yesterday following months of COVID complications. The Nerazzurri will also wear black armbands.
Milan: G Donnarumma; Calabria, Kjaer, Romagnoli, Theo Hernandez; Tonali, Kessie; Saelemaekers, Calhanoglu, Rebic; Ibrahimovic
Milan bench: Tatarusanu, A Donnarumma, Dalot, Castillejo, Hauge, Meite, Leao, Kalulu, Brahim Diaz, Tomori, Krunic, Gabbia
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Hakimi, Barella, Brozovic, Eriksen, Perisic; Lautaro Martinez, Lukaku
Inter bench: Padelli, Radu; Darmian, Kolarov, D'Ambrosio, Ranocchia; Gagliardini, Vecino, Vidal, Young; Pinamonti, Sanchez
Ref: Doveri