Milan absolutely must beat Sampdoria to stay in the European race, but a win would put Sinisa Mihajlovic’s men in fourth.
It kicks off at 19.45 UK time (18.45 GMT), click here to follow the build-up and action on our LIVEBLOG.
The Rossoneri have gone from total crisis mode to regained confidence after two consecutive victories over Cagliari and Palermo.
Milan absolutely must beat Sampdoria to stay in the European race, but a win would put Sinisa Mihajlovic’s men in fourth.
It kicks off at 19.45 UK time (18.45 GMT), click here to follow the build-up and action on our LIVEBLOG.
The Rossoneri have gone from total crisis mode to regained confidence after two consecutive victories over Cagliari and Palermo.
This is a great opportunity for them to close on the top six, but earlier results also mean Samp can leapfrog both Fiorentina and Napoli into fourth place with a win here.
These sides played a spectacular 2-2 draw at Marassi back in November, while last season Valter Birsa gave Milan the 1-0 win.
Pippo Inzaghi’s injury list is reduced, as only Riccardo Montolivo, Keisuke Honda, Michael Essien, Stephan El Shaarawy, Hachim Mastour and Michael Agazzi are still sidelined.
Sulley Muntari is left out by mutual consent, as the Ghana midfielder is not part of the club’s plans for next season, so asked not to play unless there was an emergency. He will continue to train and receive wages.
There were injury concerns over the weekend for Jack Bonaventura and Marco van Ginkel, but both are cleared to start.
Once again the trident attack is composed of Alessio Cerci, Mattia Destro and Jeremy Menez.
Sampdoria had won four on the bounce before they capitulated 2-0 at Fiorentina last week, dropping down to fifth place.
Vasco Regini is suspended, joining Alessandro De Vitis and Fabrizio Cacciatore on the absentee list.
This game means a lot to Samuel Eto’o, as the ex-Inter star returns to San Siro as an opponent.
Mihajlovic tweaks his tactics for a 4-2-3-1 system, placing Eder, Roberto Soriano and Eto’o behind centre-forward Stefano Okaka.
It means Luis Muriel is dropped to the bench, while Djamel Mesbah faces his former club, stepping in for Regini at left-back.
Milan: Diego Lopez; Abate, Paletta, Mexes, Antonelli; Van Ginkel, De Jong, Bonaventura; Cerci, Destro, Menez
Milan bench: Abbiati, Donnarumma, Alex, Bocchetti, Bonera, De Sciglio, Rami, Zapata, Mastalli, Poli, Suso, Pazzini
Sampdoria: Viviano; De Silvestri, Silvestre, Romagnoli, Mesbah; Palombo, Obiang; Eder, Soriano, Eto’o; Okaka
Sampdoria bench: Frison, Romero, Coda, Munoz, Wszolek, Acquah, Correa, Duncan, Marchionni, Rizzo, Bergessio, Djordjevic, Muriel