Milan have Riccardo Montolivo and Luiz Adriano back from the start as they host a deeply troubled Lazio side.
It kicks off at San Siro at 19.45 GMT, follow all the build-up and action as it happens on the LIVEBLOG.
The Rossoneri need to get back on track to have any chance of closing on the European places, having scraped one point from two games.
Milan have Riccardo Montolivo and Luiz Adriano back from the start as they host a deeply troubled Lazio side.
It kicks off at San Siro at 19.45 GMT, follow all the build-up and action as it happens on the LIVEBLOG.
The Rossoneri need to get back on track to have any chance of closing on the European places, having scraped one point from two games.
Juraj Kucka and M’Baye Niang are out of action, but Montolivo and Luiz Adriano return from injury to start.
Carlos Bacca hopes to end his surprising goal drought and goalkeeper Gigio Donnarumma is available again after a knock to the head left him dazed last week.
Lazio are in dire straits, as they crashed out of the Europa League on Thursday with a humiliating 3-0 home defeat to Sparta Prague.
Coach Stefano Pioli acknowledged he will not be there next season and will be fortunate to see out the current campaign.
He has a huge injury crisis to contend with, missing Abdoulay Konko, Sergej Milinkovic-Savic, Ricardo Kishna, Stefan Radu, Dusan Basta, Stefan De Vrij and Ravel Morrison.
Alessandro Matri – who is currently on loan from Milan – starts against his parent club, supported by Antonio Candreva and Felipe Anderson.
There are reports that Milan boss Sinisa Mihajlovic will take over at Lazio next term, as he spent much of his playing career with the Biancocelesti.
Lazio haven’t conquered San Siro in 25 years, earning 10 draws and 15 Serie A defeats here against Milan since the 1-0 success in September 1989. That was decided by a Paolo Maldini own goal.
The Aquile’s top flight record here is nine wins, 22 draws and 41 visits defeats.
Milan: Donnarumma; Abate, Zapata, Romagnoli, Antonelli; Honda, Bertolacci, Montolivo, Bonaventura; Bacca, Luiz Adriano
Milan bench: Abbiati, Diego Lopez, Mexes, De Sciglio, Calabria, Alex, Poli, Ely, Mauri, Locatelli, Balotelli, Boateng, Menez
Lazio: Marchetti; Patric, Bisevac, Hoedt, Braafheid; Parolo, Biglia, Lulic; Candreva, Matri, Felipe Anderson
Lazio bench: Berisha, Guerrieri, Mauricio, Gentiletti, Onazi, Cataldi, Mauri, Djordjevic, Keita, Klose