Felipe Caicedo joins Ciro Immobile upfront and Marco Parolo plus gaps in defence as Lazio host high-flying Hellas Verona.
It kicks off at the Stadio Olimpico at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Aquile booked their spot in the Champions League Round of 16 with a tense 2-2 draw against 10-man Club Brugge.
Felipe Caicedo joins Ciro Immobile upfront and Marco Parolo plus gaps in defence as Lazio host high-flying Hellas Verona.
It kicks off at the Stadio Olimpico at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Aquile booked their spot in the Champions League Round of 16 with a tense 2-2 draw against 10-man Club Brugge.
Luis Alberto is out with a muscular problem, joined on the absentee list by Luiz Felipe, Patric, Senad Lulic and Vedat Muriqi.
Jean-Louis Akpa Akpro therefore steps into midfield, while Parolo has to plug the gaps in defence.
Caicedo is chosen to partner Immobile, allowing Joaquin Correa a rare rest.
Verona have Federico Ceccherini suspended, with Nikola Kalinic, Mert Cetin, Ronaldo Vieira and Marco Benassi carrying knocks.
Miguel Veloso is back pulling the midfield strings behind Antonin Barak, Mattia Zaccagni and Eddie Salcedo.
Lazio: Reina; Parolo, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Akpa Akpro, Marusic; Caicedo, Immobile
Verona: Silvestri; Lovato, Dawidowicz, Magnani; Faraoni, Tameze, Miguel Veloso, Dimarco; Barak, Zaccagni; Salcedo
Ref: Abisso