Lazio go for a club record 10th consecutive Serie A victory with Ciro Immobile and Felipe Caicedo, while Napoli are transformed by injuries.
It kicks off at the Stadio Olimpico at 17.00 GMT.
You can follow all the build-up and action as it happens from that game and Inter–Atalanta on the LIVEBLOG.
Lazio go for a club record 10th consecutive Serie A victory with Ciro Immobile and Felipe Caicedo, while Napoli are transformed by injuries.
It kicks off at the Stadio Olimpico at 17.00 GMT.
Simone Inzaghi’s men look unstoppable at the moment, beating Juventus 3-1 to lift the Supercoppa Italiana in December and matching Sven Goran Eriksson’s 1998-99 record of nine straight Serie A wins.
They can therefore make history today by taking that streak to 10, something Lazio have never achieved before.
On the other hand, Napoli are in crisis and new coach Gennaro Gattuso lost two of his three games in charge, scraping a stoppage-time victory over Sassuolo in the other.
This weekend is the midway mark in the season and the Partenopei are languishing in eighth place, already 11 points adrift of the Champions League places.
The situation is not helped by a slew of injuries, as Alex Meret and Amin Younes have now joined Kalidou Koulibaly, Nikola Maksimovic, Faouzi Ghoulam, Dries Mertens and Kevin Malcuit on the treatment table.
It means David Ospina goes in goal, with Giovanni Di Lorenzo again shifted to centre-back with Kostas Manolas.
Jose Callejon is preferred to Hirving Lozano in a 4-3-3 with Arkadiusz Milik and Lorenzo Insigne.
Lazio have Marco Parolo suspended, with Adam Marusic, Denis Vavro and Jordan Lukaku injured, but Luis Alberto and Lucas Leiva return from their bans, having missed the 2-1 win at Brescia.
Joaquin Correa is not even fit for the bench, but Senad Lulic grits his teeth to play despite an ankle problem, so Felipe Caicedo partners native Neapolitan and runaway Capocannoniere Immobile.
This is the best chance Lazio have had in many years to break this taboo, because they’ve lost their last five Serie A meetings with Napoli, home and away, since a 4-2 result at the San Paolo in May 2015.
In fact, the Partenopei have emerged with a victory from their last six league trips to the Olimpico.
Lazio: Strakosha; Luiz Felipe, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Caicedo, Immobile
Lazio bench: Guerrieri, Proto, Patric, Berisha, Bastos, Jony, Andre Anderson, Cataldi, Adekanye, Jorge Silva
Napoli: Ospina; Hysaj, Di Lorenzo, Manolas, Mario Rui; Fabian Ruiz, Allan, Zielinski; Callejon, Milik, Insigne
Napoli bench: Karnezis, Daniele, Luperto, Tonelli, Elmas, Gaetano, Llorente, Lozano
Ref: Orsato