Zlatan Ibrahimovic is out of action, so Mario Mandzukic steps in for Milan in this head-to-head for Champions League places with Ciro Immobile’s Lazio.
It kicks off at the Stadio Olimpico in Rome at 19.45 UK time (18.45 GMT).
You can follow the build-up and action as it happens from this game and Torino–Napoli on the LIVEBLOG.
Zlatan Ibrahimovic is out of action, so Mario Mandzukic steps in for Milan in this head-to-head for Champions League places with Ciro Immobile’s Lazio.
It kicks off at the Stadio Olimpico in Rome at 19.45 UK time (18.45 GMT).
This is a big fixture for both clubs, as defeat would almost certainly rule Lazio out of the running for the top four, whereas anything less than a win would see Milan lose second place to Atalanta.
Ibrahimovic is still out injured after missing the 2-1 defeat to Sassuolo, so Mandzukic gets his first start in the Rossoneri jersey.
Theo Hernandez and Ismael Bennacer also missed the midweek game, but are passed fit to start.
Lazio are coming off a chaotic 5-2 defeat to Napoli that dented their European hopes, but they still have a game in hand to be played against Torino on May 18.
Lucas Leiva and Luis Alberto are not at their best, but grit their teeth to start anyway.
Felipe Caicedo, Gonzalo Escalante and long-term absentee Luiz Felipe are out of action, so Adam Marusic is confirmed as a defender.
Ciro Immobile is partnered by Joaquin Correa.
The big news for Lazio is the return of coach Simone Inzaghi, who had missed the last few games after testing positive for COVID.
When these sides met at San Siro in December, it was a dramatic 3-2 Milan victory in stoppages.
Lazio: Reina; Marusic, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Correa, Immobile
Lazio bench: Alia, Strakosha; Hoedt, Musacchio, Patric; Akpa Akpro, Cataldi, Fares, Parolo, Pereira; Muriqi
Milan: G Donnarumma; Calabria, Kjaer, Tomori, Theo Hernandez; Bennacer, Kessie; Saelemaekers, Calhanoglu, Rebic; Mandzukic
Milan bench: Tatarusanu; Dalot, Gabbia, Kalulu, Romagnoli; Castillejo, Brahim Diaz, Hauge, Krunic, Meite, Tonali; Leao
Ref: Orsato