Juventus unite Paulo Dybala with Cristiano Ronaldo for the Scudetto showdown, while Napoli have Piotr Zielinski and Dries Mertens.
It kicks off in Turin at 17.00 UK time (16.00 GMT), follow the build-up and action as it happens on the LIVEBLOG.
These two sides battled to the bitter end for the title last season and Juve got their seventh in a row, despite Kalidou Koulibaly’s header giving Napoli the 1-0 victory here.
Juventus unite Paulo Dybala with Cristiano Ronaldo for the Scudetto showdown, while Napoli have Piotr Zielinski and Dries Mertens.
It kicks off in Turin at 17.00 UK time (16.00 GMT), follow the build-up and action as it happens on the LIVEBLOG.
These two sides battled to the bitter end for the title last season and Juve got their seventh in a row, despite Kalidou Koulibaly’s header giving Napoli the 1-0 victory here.
Both teams have changed a great deal over the last 160 days since that game and it is reflected in the line-ups.
Dybala is chosen rather than Federico Bernardeschi to complete the trident attack with Cristiano Ronaldo and Mario Mandzukic.
Sami Khedira, Mattia De Sciglio, Leonardo Spinazzola and suspended Douglas Costa miss out, so Emre Can steps in to midfield.
Joao Cancelo and Alex Sandro are chosen as the full-backs in a 4-3-3 formation.
Carlo Ancelotti has transformed Maurizio Sarri’s tactics, adopting a 4-4-2 that puts Lorenzo Insigne in a more central role and moving Jose Callejon deeper.
He is partnered in attack by Dries Mertens rather than Arkadiusz Milik, even though the Pole scored a brace in the midweek victory over Parma.
With Alex Meret, Amin Younes, Vlad Chiriches and Faouzi Ghoulam injured, the only other doubt was wide left between Piotr Zielinski and Simone Verdi, with the Poland international getting the nod.
Last season, Koulibaly’s header ended a run of one point from Napoli’s last nine competitive trips to Turin.
Expect a low-scoring affair, as four of the last five Serie A fixtures between these sides have ended in Under 2.5 goals.
Juventus: Szczesny; Cancelo, Bonucci, Chiellini, Alex Sandro; Can, Pjanic, Matuidi; Dybala, Mandzukic, Ronaldo
Juventus bench: Perin, Pinsoglio, Barzagli, Benatia, Rugani, Bentancur, Cuadrado, Bernardeschi, Kean
Napoli: Ospina; Hysaj, Albiol, Koulibaly, Mario Rui; Callejon, Allan, Hamsik, Zielinski; Insigne, Mertens
Napoli bench: Karnezis, D’Andrea, Maksimovic, Luperto, Malcuit, Fabian, Rog, Diawara, Verdi, Milik, Ounas