Juventus debut Miralem Pjanic, while Gonzalo Higuain and Paulo Dybala get their first start together when hosting a reshuffled Sassuolo.
It kicks off in Turin at 17.00 UK time (16.00 GMT), follow the build-up and action on the LIVEBLOG.
Max Allegri revamps his side with Pjanic finally given his competitive Bianconeri debut in a deep-lying midfield role, albeit with more freedom to roam than Andrea Pirlo had.
Juventus debut Miralem Pjanic, while Gonzalo Higuain and Paulo Dybala get their first start together when hosting a reshuffled Sassuolo.
It kicks off in Turin at 17.00 UK time (16.00 GMT), follow the build-up and action on the LIVEBLOG.
Max Allegri revamps his side with Pjanic finally given his competitive Bianconeri debut in a deep-lying midfield role, albeit with more freedom to roam than Andrea Pirlo had.
Mario Lemina and Sami Khedira keep their spots, moving Kwadwo Asamoah to the bench, while it’s the first start together for Argentines Higuain and Dybala – partners already nicknamed Juve-HD.
Stephan Lichtsteiner is off the Champions League list, but thrown in from the start here because Juan Cuadrado and Dani Alves only returned from international duty yesterday.
Andrea Barzagli is rested in favour of Medhi Benatia and a special atmosphere is expected five years on from the opening of the Juventus Stadium.
Sassuolo technically won their first two games of the season, but the 2-1 victory over Pescara was overturned by the Disciplinary Commission due to the failure to register Antonino Ragusa.
Ragusa is given a start today, hopefully with the right paperwork, with Matteo Politano and ex-Juve striker Alessandro Matri.
That’s because Berardi and Gregoire Defrel are both on the treatment table.
There are some surprises in the line-up, as Paolo Cannavaro and Simone Missiroli are on the bench in favour of Luca Antei and Lorenzo Pellegrini.
Sassuolo have lost all three previous Serie A visits to Turin without scoring a single goal, but Eusebio Di Francesco’s side have been on sparkling form in Italy and the Europa League.
Juventus: Buffon; Benatia, Bonucci, Chiellini; Lichtsteiner, Khedira, Pjanic, Lemina, Alex Sandro; Dybala, Higuain
Juventus bench: Neto, Audero, Dani Alves, Barzagli, Rugani, Evra, Hernanes, Asamoah, Cuadrado, Pjaca, Mandzukic
Sassuolo: Consigli; Gazzola, Antei, Acerbi, Peluso; Pellegrini, Magnanelli, Duncan; Politano, Matri, Ragusa
Sassuolo bench: Pomini, Pegolo, Missiroli, Biondini, Iemmello, Lirola, Mazzitelli, Terranova, Ricci, Cannavaro, Letschert, Adjapong