Juventus go for three at the back and start Daniele Rugani as they host Sassuolo, but Domenico Berardi is ruled out.
It kicks off at the Juventus Stadium in Turin at 19.45 GMT, follow the build-up and action on our LIVEBLOG.
The Bianconeri have to balance staying top of the Serie A table with preparing for Wednesday’s Champions League showdown with Bayern Munich.
Max Allegri has to do without the injured Giorgio Chiellini and Martin Caceres.
Juventus go for three at the back and start Daniele Rugani as they host Sassuolo, but Domenico Berardi is ruled out.
It kicks off at the Juventus Stadium in Turin at 19.45 GMT, follow the build-up and action on our LIVEBLOG.
The Bianconeri have to balance staying top of the Serie A table with preparing for Wednesday’s Champions League showdown with Bayern Munich.
Max Allegri has to do without the injured Giorgio Chiellini and Martin Caceres.
Stephan Lichtsteiner and Paul Pogba are rested, so Rugani gets a rare start in the three-man defence.
Paulo Dybala and Mario Mandzukic work on their partnership up front, meaning ex-Sassuolo striker Simone Zaza is only on the bench.
Berardi isn’t even in the stadium, as the Neroverdi’s star player is suffering from flu symptoms and hasn’t recovered sufficiently.
It’s a blow for Eusebio Di Francesco, who is already missing Paolo Cannavaro, Simone Missiroli, Karim Laribi and the suspended forward Gregoire Defrel.
The 4-3-3 system remains intact, but with new entries Matteo Politano and Diego Falcinelli to support Italy international Nicola Sansone.
This represents an early taste of the Allianz Arena for Juventus, as Sansone was born in Munich and grew up in the Bayern academy.
Sassuolo were the last side to beat Juventus all the way back in October, so can they upset the Old Lady again?
Juventus: Buffon; Rugani, Bonucci, Barzagli; Cuadrado, Khedira, Marchisio, Asamoah, Alex Sandro; Dybala, Mandzukic
Sassuolo: Consigli; Vrsaljko, Acerbi, Antei, Peluso; Duncan, Magnanelli, Biondini; Politano, Falcinelli, Sansone