Juventus revamp their defence and midfield to take on Pescara, but it’s Mario Mandzukic and Gonzalo Higuain together again.
It kicks off in Turin at 19.45 GMT, follow the build-up and action on the LIVEBLOG.
The Bianconeri have the opportunity to extend their lead at the top of the table, as the chasing pack all have considerably more difficult fixtures on paper this weekend.
Juventus revamp their defence and midfield to take on Pescara, but it’s Mario Mandzukic and Gonzalo Higuain together again.
It kicks off in Turin at 19.45 GMT, follow the build-up and action on the LIVEBLOG.
The Bianconeri have the opportunity to extend their lead at the top of the table, as the chasing pack all have considerably more difficult fixtures on paper this weekend.
Max Allegri has quite a few injury problems to deal with, missing Andrea Barzagli for two months with a dislocated shoulder, Marko Pjaca, Paulo Dybala and Medhi Benatia.
Dani Alves is rested after international duty in Brazil, as he needs to be fresh for the Champions League showdown with Sevilla next week.
Also rested are Gigi Buffon, Miralem Pjanic, Giorgio Chiellini and Claudio Marchisio.
Moise Kean is on the bench again, as the 16-year-old is consistently expected to make his debut at senior level, but so far hasn’t been given a chance yet.
Daniele Rugani started Italy’s 0-0 friendly with Germany on Tuesday and is given a rare opportunity to shine in a reshuffled back three.
Pescara have not actually won a game this season, as the only victory was handed to them by the Disciplinary Commission for Sassuolo fielding an ineligible player.
That decision is still the subject of another appeal by the Neroverdi.
Massimo Oddo’s side have played some decent football, but before the break for international duty were humiliated 4-0 on home turf by Empoli.
Andrea Coda, Jean-Christophe Bahebeck, Norbert Gyomber and Valerio Verre haven’t even made the trip to Turin.
Gaston Brugman and Bryan Cristante form the midfield, while Gianluca Caprari leads the attack.
Pescara have played this fixture six times in Serie A and earned one point, a 1-1 draw in February 1989.
Juve won their last four encounters with the Delfini, home and away in all competition, since a shock 5-1 loss at the Adriatico in May 1993.
Juventus: Neto; Rugani, Bonucci, Evra; Lichtsteiner, Khedira, Hernanes, Asamoah, Alex Sandro; Mandzukic, Higuain
Juventus bench: Buffon, Audero, Chiellini, Sturaro, Pjanic, Lemina, Marchisio, Cuadrado, Kean
Pescara: Bizzarri; Campagnaro (Vitturini 46), Zuparic, Biraghi; Zampano, Cristante, Brugman, Crescenzi; Memushaj; Pettinari, Caprari
Pescara bench: Fiorillo, Vitturini, Pepe, Muric, Aquilani, Benali, Manaj, Bruno