Inter use Christian Eriksen behind the strikers and Roberto Gagliardini in midfield, while Sampdoria transform their tactics in the absence of Fabio Quagliarella.
It kicks off at 20.45 UK time (19.45 GMT) behind closed doors at San Siro.
You can follow all the build-up and action as it happens from this game and Atalanta–Sassuolo on the LIVEBLOG.
Inter use Christian Eriksen behind the strikers and Roberto Gagliardini in midfield, while Sampdoria transform their tactics in the absence of Fabio Quagliarella.
It kicks off at 20.45 UK time (19.45 GMT) behind closed doors at San Siro.
Antonio Conte was left disappointed by the Coppa Italia semi-final 1-1 draw with Napoli last week, which saw them crash out 2-1 on aggregate.
He has to get them back on track in Serie A with this rescheduled Week 25 fixture, but Marcelo Brozovic, Stefano Sensi and Matias Vecino are out of action.
Therefore, Gagliardini comes into the midfield rather than Borja Valero, with Eriksen given a trequartista slot behind Romelu Lukaku and Lautaro Martinez.
Sampdoria are forced into changes too, as the relegation-threatened side make the trip without top scorer Quagliarella and defender Alex Ferrari.
Gaston Ramirez leads the line with Antonino La Gumina rather than Manolo Gabbiadini, but the biggest difference is that Claudio Ranieri moves to three at the back in order to mirror Conte’s system.
Omar Colley was not 100 per cent fit, but he’s in the starting XI instead of Lorenzo Tonelli.
Inter lost to Lazio and Juventus before the lockdown, so Conte could suffer three consecutive Serie A defeats for the first time since he was on the Atalanta bench in 2009.
The Nerazzurri will wear black armbands following the death of legendary player Mario Corso, aged 78.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Candreva, Barella, Gagliardini, Young; Eriksen; R Lukaku, Lautaro Martinez
Inter bench: Berni, Godin, Alexis Sanchez, Moses, Ranocchia, Asamoah, Borja Valero, Esposito, Pirola, Agoume, D’Ambrosio, Biraghi
Sampdoria: Audero; Bereszynski, Yoshida, Colley; Thorsby, Linetty, Bertolacci, Jankto, Murru; Ramirez, La Gumina
Sampdoria bench: Falcone, Augello, Vieira, Chabot, Ekdal, Bonazzoli, Depaoli, Askildsen, Tonelli, Gabbiadini, Leris, Rocha
Ref: Mariani