Inter use Stevan Jovetic, Mauro Icardi and Ivan Perisic against the Napoli trident Jose Callejon, Manolo Gabbiadini and Lorenzo Insigne.
It kicks off at San Siro at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
This is a huge game in any season, but even more so when the Nerazzurri need points to stay in the hunt for a Champions League spot and the Partenopei have to keep their Scudetto hopes alive.
Inter use Stevan Jovetic, Mauro Icardi and Ivan Perisic against the Napoli trident Jose Callejon, Manolo Gabbiadini and Lorenzo Insigne.
It kicks off at San Siro at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
This is a huge game in any season, but even more so when the Nerazzurri need points to stay in the hunt for a Champions League spot and the Partenopei have to keep their Scudetto hopes alive.
It is also the first time Roberto Mancini and Maurizio Sarri have crossed paths since their ugly touchline spat in January’s Coppa Italia quarter-final.
Mancio has assured he will shake Sarri’s hand this evening, but it’s the chance for Napoli to take revenge after that 2-0 Coppa defeat at the San Paolo.
Inter have a full squad at their disposal and Mancini shakes things up again, giving Geoffrey Kondogbia his first start since March 6.
Jovetic and Perisic support hitman Icardi in the trident attack with Marcelo Brozovic in midfield.
Gonzalo Higuain saw his four-match ban reduced to three on appeal, so he will be available against Roma, but has another two to sit out.
Napoli did well enough in his absence, beating Verona 3-0, but this will be the first truly big test since Pipita’s suspension.
Gabbiadini – a known transfer target for Inter – leads the attack with support from Insigne, Callejon and Marek Hamsik.
Kalidou Koulibaly and Dries Mertens return from their bans.
Ivan Strinic is a surprise at left-back in place of Faouzi Ghoulam.
Napoli are unbeaten in their last six Serie A encounters with Inter, winning half of them.
We should see some entertainment, as both teams have found the target in six of the last seven Serie A meetings.
However, the Partenopei have won only one of their most recent 12 visits to San Siro, drawing two and losing nine.
Inter: Handanovic; D'Ambrosio, Miranda, Murillo, Nagatomo; Brozovic, Medel, Kondogbia; Jovetic, Icardi, Perisic
Inter bench: Carrizo, Berni, Juan Jesus, Palacio, Biabiany, Telles, Ljajic, Eder, Gnoukouri, Melo, Manaj
Napoli: Reina; Hysaj, Albiol, Koulibaly, Strinic; Allan, Jorginho, Hamsik; Callejon, Gabbiadini, Insigne
Napoli bench: Gabriel, Rafael, Valdifiori, Maggio, Mertens, Regini, David Lopez, Chiriches, Ghoulam, El Kaddouri, Grassi, Chalobah