Inter can maintain their four-point lead at the top of the table and potentially get Lazio Coach Stefano Pioli sacked.
It kicks off at San Siro at 19.45 GMT, follow the action as it happens on our LIVEBLOG.
The Nerazzurri need a result here to avoid Napoli, Fiorentina and Juventus closing on the League leaders before the Christmas break.
Andrea Ranocchia is the only absentee for Inter and he wouldn’t have featured anyway.
Inter can maintain their four-point lead at the top of the table and potentially get Lazio Coach Stefano Pioli sacked.
It kicks off at San Siro at 19.45 GMT, follow the action as it happens on our LIVEBLOG.
The Nerazzurri need a result here to avoid Napoli, Fiorentina and Juventus closing on the League leaders before the Christmas break.
Andrea Ranocchia is the only absentee for Inter and he wouldn’t have featured anyway.
Roberto Mancini loves to chop and change his formation, so Stevan Jovetic and Mauro Icardi start together with Jonathan Biabiany and Ivan Perisic, dropping on-form Adem Ljajic.
Lazio have huge problems selecting a team, as there’s a crowded treatment table.
Out of action are Miroslav Klose, Federico Marchetti, Stefan de Vrij, Dusan Basta, Santiago Gentiletti, Ricardo Kishna and Senad Lulic, while Ravel Morrison was given permission to leave early for a family funeral.
That means Felipe Anderson has to take the reins with Alessandro Matri and Antonio Candreva.
It’s a special game for Candreva, as Inter have been heavily linked with a January offer for the midfielder.
Inter: Handanovic; Montoya, Miranda, Murillo, Telles; Melo, Medel; Biabiany, Jovetic, Perisic; Icardi
Lazio: Berisha; Konko, Mauricio, Hoedt, Radu; Milinkovic-Savic, Biglia, Parolo; Candreva, Matri, Felipe Anderson