Stefano Pioli makes some more surprising changes in search of his first Inter win, hosting a Fiorentina side with their own problems.
It kicks off at San Siro at 20.00 GMT, follow the build-up and action to this and Napoli–Sassuolo on the LIVEBLOG.
Both these sides risk sliding further away from the chase for Champions League football and Inter already suffered a stinging blow on Thursday.
Stefano Pioli makes some more surprising changes in search of his first Inter win, hosting a Fiorentina side with their own problems.
It kicks off at San Siro at 20.00 GMT, follow the build-up and action to this and Napoli-Sassuolo on the LIVEBLOG.
Both these sides risk sliding further away from the chase for Champions League football and Inter already suffered a stinging blow on Thursday.
They were 2-0 up at Hapoel Be’er-Sheva only to lose 3-2 and crash out of the Europa League in the group phase, something that had never happened to the club before.
New Coach Pioli is still looking for his first win on the bench after a dramatic 2-2 Milan Derby draw and that midweek shocker.
It’s not a great fixture to turn things around, because Fiorentina have beaten Inter in each of their last four meetings, home and away.
Last season this game ended 4-1 to the Viola with a Nikola Kalinic hat-trick.
Gary Medel, Rodrigo Palacio and Davide Santon are out injured, but Pioli is no fan of Jeison Murillo, as the Colombian was benched for the derby in favour of Medel.
Andrea Ranocchia is given a surprise starting spot instead alongside Joao Miranda, while Marcelo Brozovic is increasingly the go-to man in midfield after being shelved by Frank de Boer.
Mauro Icardi, Ivan Perisic and Antonio Candreva lead the attack, but a big problem for Inter this season has been that too few players have found the net, so they rely too heavily on their captain.
Ever Banega gets the nod rather than Joao Mario in midfield, despite the Portugal international not playing in Europe midweek.
Fiorentina have problems of their own, as the fans placed banners on the training ground gates urging Paulo Sousa to resign.
He seems disillusioned with the club and their lack of ambition right now, which is reflected in less scintillating performances than we were used to last season.
Kalinic got a hat-trick here last term, while Federico Bernardeschi and Milan Badelj have been heavily linked with a move to Inter, so they’ll want to impress.
The Viola are unbeaten at San Siro since September 2013, coming away with two consecutive victories in which they scored five goals and conceded one.
Inter: Handanovic; D'Ambrosio, Ranocchia, Miranda, Ansaldi; Brozovic, Kondogbia; Candreva, Banega, Perisic; Icardi
Inter bench: Carrizo, Andreolli, Murillo, Nagatomo, Miangue, Felipe Melo, Gnoukouri, Joao Mario, Biabiany, Eder, Jovetic, Gabriel Barbosa
Fiorentina: Tatarusanu; Gonzalo Rodriguez, Salcedo, Astori, Milic; Badelj, Borja Valero; Tello, Ilicic, Bernardeschi; Kalinic
Fiorentina bench: Lezzerini, Dragowski, Tomovic, De Maio, Maxi Olivera, Sanchez, Cristoforo, Vecino, Chiesa, Perez, Zarate, Babacar