Fiorentina revamp their side by dropping Federico Bernardeschi, while Napoli hope Gonzalo Higuain and Lorenzo Insigne break their drought.
It kicks off at 20.00 GMT, follow all the build-up and action from this and Lazio v Sassuolo on our LIVEBLOG.
This is a huge game for the Champions League and Scudetto, because Fiorentina are in third and Napoli second, the Partenopei needing a result to close the gap on Juventus.
Fiorentina revamp their side by dropping Federico Bernardeschi, while Napoli hope Gonzalo Higuain and Lorenzo Insigne break their drought.
It kicks off at 20.00 GMT, follow all the build-up and action from this and Lazio v Sassuolo on our LIVEBLOG.
This is a huge game for the Champions League and Scudetto, because Fiorentina are in third and Napoli second, the Partenopei needing a result to close the gap on Juventus.
Mauro Zarate is suspended with Yohan Benalouane injured, but Paulo Sousa makes changes after the 3-0 Europa League defeat to Tottenham on Thursday night.
Josip Ilicic and Federico Bernardeschi are dropped in favour of a new system with Nikola Kalinic in attack.
Napoli are missing Omar El Kaddouri and Ivan Strinic, but that makes little difference to Maurizio Sarri’s usual first choice XI.
Gonzalo Higuain scored 24 goals in the first 24 Serie A rounds, but has now fired blanks for four games in all competition.
Coincidence? Napoli failed to win any of them. They too crashed out of the Europa League this week to Villarreal, a 1-1 draw at the San Paolo unable to overturn the 1-0 defeat in Spain.
Lorenzo Insigne is ready to start despite the scare of being robbed at gunpoint while out with his wife on Saturday night.
Fiorentina: Tatarusanu; Roncaglia, Gonzalo Rodriguez, Astori, Alonso; Badelj, Vecino; Tello, Borja Valero, Mati Fernandez; Kalinic
Fiorentina bench: Lezzerini, Satalino, Tomovic, Costa, Bernardeschi, Kuba, Pasqual, Kone, Babacar, Ilicic
Napoli: Reina; Hysaj, Albiol, Koulibaly, Ghoulam; Allan, Jorginho, Hamsik; Callejon, Higuain, Insigne
Napoli bench: Gabriel, Rafael, Maggio, Luperto, Regini, Chiriches, David Lopez, Grassi, Chalobah, Valdifiori, Mertens, Gabbiadini